Rheumatic Heart Disease Clinical Trial
Official title:
Screening and Secondary Prevention Rheumatic Heart Disease
After basic clinical screening including history and physical, Point of care ultrasound will be performed to look at Mitral, Aortic and Tricuspid Valves for regurgitation or stenosis. For patients with confirmed Rheumatic heart disease (RHD), treatment and referral depending on stage of disease. Antibiotic prescription could be shifted to community health workers delivering preventive medications via practical clinical algorithms, diagnostic tools, availability of appropriate antibiotics, and supportive supervision. Patients will have repeat imaging at 2 years and 5 years to look at the outcome of delayed progression of valve disease.
Screening for RHD should be carried out since it is a major health concern that has been shown to have a treatable and detectable latent stage that can be diagnosed using a simple sensitive test (point of care ultrasound) and early treatment (secondary prevention using antibiotic prophylaxis) can provide a better outcome (slow progression of disease) in a cost effective way. The investigators aim to study the Incidence and Prevalence of RHD in community and school settings and aim to intervene depending on the stage the disease is picked up in. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02661763 -
Rheumatic Heart Disease Study in Lusaka
|
N/A | |
| Completed |
NCT02188862 -
Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region
|
N/A | |
| Completed |
NCT01178710 -
Effect of Simvastatin on Cardiac Function
|
N/A | |
| Recruiting |
NCT05693545 -
GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial
|
Phase 2 | |
| Completed |
NCT06150274 -
Comparison of Wire Assisted Percutaneous Balloon Mitral Valvulotomy With Standard Inoue Balloon Valvulotomy
|
N/A | |
| Terminated |
NCT03926156 -
RIvoraxaban in Mitral Stenosis
|
Phase 3 | |
| Recruiting |
NCT05783375 -
Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda
|
N/A | |
| Completed |
NCT02474108 -
Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement
|
N/A | |
| Recruiting |
NCT04556188 -
The Clinical Influence of Developing a Sustainable Cardiac Surgery Service to Reduce the Burden of Rheumatic Heart Disease in Sub-Saharan Africa
|
||
| Recruiting |
NCT03991910 -
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients
|
Phase 3 | |
| Active, not recruiting |
NCT03346525 -
Determining the Impact of Penicillin in Latent RHD: The GOAL Trial
|
Phase 2 | |
| Recruiting |
NCT05504928 -
Effectiveness of a School-centered Prevention Program on Prevalence of Latent Rheumatic Heart Disease
|
N/A | |
| Not yet recruiting |
NCT03549052 -
Right Ventricular Echo Assessment in Mitral Valve Replacement
|
||
| Recruiting |
NCT05487469 -
Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass
|
N/A | |
| Completed |
NCT05276999 -
Rheumatic Heart Disease Community Streptococcal Treatment Program "RESET"
|
N/A | |
| Completed |
NCT05668611 -
Train the Trainer Curriculum to Scale up AI Supported Echo for RHD Screening in a Public Health System
|
N/A | |
| Active, not recruiting |
NCT05211024 -
A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post)
|
||
| Withdrawn |
NCT02832531 -
INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority
|
Phase 3 | |
| Completed |
NCT01794884 -
Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery
|
Phase 2 | |
| Completed |
NCT00264524 -
DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease
|
N/A |