Rheumatic Heart Disease Community Streptococcal Treatment Program "RESET"

Status Completed

Clinical Trial Summary

The primary objective of this study is to determine the impact of a pragmatic RHD primary prevention program in Uganda. The secondary Objective are as follow: 1. To improve guideline-based care for sore throat through frontline healthcare provider education on clinical decision rules and guideline-based primary prevention. 2. To increase health seeking behavior for sore throat thorough a multifaceted community awareness campaign.

Clinical Trial Description

Our intervention is designed as a service-oriented plan to be implemented through the primary healthcare structure and facilities of both the national health and private system. Additional support will come from the education system, with participation from schools, teachers, patients, patient families, and the public. Our intervention will focus on two of the more easily rectified impediments to primary prevention, namely (1) poor uptake of guideline-based treatments for Group A Streptococcal (GAS) pharyngitis and (2) low levels of public awareness of the importance of sore throat care and treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05276999
Study type	Interventional
Source	Children's Hospital Medical Center, Cincinnati
Contact
Status	Completed
Phase	N/A
Start date	January 31, 2022
Completion date	March 30, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05991219` - Screening and Secondary Prevention Rheumatic Heart Disease Study
Completed	`NCT02661763` - Rheumatic Heart Disease Study in Lusaka	N/A
Completed	`NCT02188862` - Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region	N/A
Completed	`NCT01178710` - Effect of Simvastatin on Cardiac Function	N/A
Recruiting	`NCT05693545` - GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial	Phase 2
Completed	`NCT06150274` - Comparison of Wire Assisted Percutaneous Balloon Mitral Valvulotomy With Standard Inoue Balloon Valvulotomy	N/A
Terminated	`NCT03926156` - RIvoraxaban in Mitral Stenosis	Phase 3
Recruiting	`NCT05783375` - Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda	N/A
Completed	`NCT02474108` - Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement	N/A
Recruiting	`NCT04556188` - The Clinical Influence of Developing a Sustainable Cardiac Surgery Service to Reduce the Burden of Rheumatic Heart Disease in Sub-Saharan Africa
Recruiting	`NCT03991910` - The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients	Phase 3
Active, not recruiting	`NCT03346525` - Determining the Impact of Penicillin in Latent RHD: The GOAL Trial	Phase 2
Recruiting	`NCT05504928` - Effectiveness of a School-centered Prevention Program on Prevalence of Latent Rheumatic Heart Disease	N/A
Not yet recruiting	`NCT03549052` - Right Ventricular Echo Assessment in Mitral Valve Replacement
Recruiting	`NCT05487469` - Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass	N/A
Completed	`NCT05668611` - Train the Trainer Curriculum to Scale up AI Supported Echo for RHD Screening in a Public Health System	N/A
Active, not recruiting	`NCT05211024` - A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post)
Withdrawn	`NCT02832531` - INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority	Phase 3
Completed	`NCT01794884` - Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery	Phase 2
Completed	`NCT00264524` - DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease	N/A