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Clinical Trial Summary

Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS (CONSYST-CRT randomized clinical trial) is a non-inferiority trial that aims to study the composite endpoint consisting of all-cause mortality, cardiac transplant, heart failure hospitalizations, and left ventricular ejection fraction (LVEF) improvement <5 points.

Clinical Trial Description

To date, studies have shown that conduction system pacing could get similar clinical and echocardiographic responses to those obtained with biventricular therapy. This study will randomize 130 patients to a strategy of biventricular pacing versus conduction system pacing. CONSYST-CRT study will analyze the following parameters in the 2 groups: left ventricular ejection fraction, ventricular volumes, echocardiographic response (>=15% decrease in left ventricular end-systolic volume), NYHA functional class, heart failure hospitalization, all-cause mortality, cardiac transplant, QRS shortening, echocardiographic asynchrony (septal flash). Clinical, electrocardiographic, echocardiographic follow-up will be performed for 1 year. The first 70 patients have been recruited in the context of the LEVELAT study ( Identifier: NCT04054895) ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05187611
Study type Interventional
Source Hospital Clinic of Barcelona
Contact Lluís Mont, MD, PhD
Phone +34 93 2271778
Email [email protected]
Status Recruiting
Phase N/A
Start date January 17, 2022
Completion date January 2024

See also
  Status Clinical Trial Phase
Active, not recruiting NCT04054895 - LEft VEntricuLar Activation Time Shortening With Physiological Pacing vs Biventricular Resynchronization Therapy N/A
Completed NCT01996397 - Acute Feedback on Left ventrIcular Lead Implantation Location for Cardiac Resynchronization Therapy N/A
Recruiting NCT05155865 - Conduction System Pacing Versus Biventricular Pacing for Cardiac resYNChronization N/A