Restless Legs Syndrome Clinical Trial
Official title:
Prevalence of Restless Legs Syndrome in Patients With Unpleasant Sensations of the Legs
| NCT number | NCT00557258 |
| Other study ID # | 248.652 |
| Secondary ID | |
| Status | Completed |
| Phase | N/A |
| First received | November 9, 2007 |
| Last updated | February 12, 2009 |
| Start date | November 2007 |
The proposed study is a Cross-sectional epidemiological study, performed in 330 primary care
practices in Germany. The study will be conducted on a fixed day in November 2007.
Primary care surgeries throughout Germany will be asked to take part. The study material
will be delivered to the surgery by a member of sales-force who will also explain the study
conduct to the physician/staff. Physicians who want to take part in the study will send a
signed contract to BI. Physicians will be trained to diagnose RLS.
All patients attending the participating surgeries on a fixed day will be invited to
participate in the study. The patients will be handed a questionnaire to fill out while
waiting for their appointment. No patient-related data apart from gender and year of birth
will be recorded on the questionnaire and it will be ensured that no re-identification of
patients is possible. Therefore, no written informed consent will be obtained from the
participants.
The patient questionnaire will consist of the following items:
A screening questionnaire for RLS (according to Stiasny-Kolster et. al., data on file)
Additional questions concerning the impact of the patients leg problems on daily life.
The practice staff will then collect the questionnaire. All patients who have answered
question 1 (asking for unpleasant sensations of the legs) with ¿Yes¿ will subsequently be
assessed for the diagnosis by the physician.
The physician fills out a second questionnaire, covering the following items:
Diagnosis (cause of leg problems) Concomitant diagnoses and therapies If the diagnosis of
RLS was made: consequences (therapy)? Was the diagnosis of RLS pre-known? All completed
questionnaires will be sent to data management by the surgery within 2 working days.
| Status | Completed |
| Enrollment | 14956 |
| Est. completion date | |
| Est. primary completion date | November 2007 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - Patients attending one of the participating primary care surgeries on a fixed day - Male or female patients of any age Exclusion Criteria: - Patients who only attend the practice to get a prescription and are not seen by the doctor on that day. - Patients who are not able to understand the questionnaire due to mental impairment or language problems. - Children and adolescents under the age of 18 years |
N/A
| Country | Name | City | State |
|---|---|---|---|
| Germany | Boehringer Ingelheim Investigational Site | Aachen | |
| Germany | Boehringer Ingelheim Investigational Site | Aalen | |
| Germany | Boehringer Ingelheim Investigational Site | Ahlen | |
| Germany | Boehringer Ingelheim Investigational Site | Altena | |
| Germany | Boehringer Ingelheim Investigational Site | Altensteig | |
| Germany | Boehringer Ingelheim Investigational Site | Altomünster | |
| Germany | Boehringer Ingelheim Investigational Site | Alveslohe | |
| Germany | Boehringer Ingelheim Investigational Site | Annaberg-Buchholz | |
| Germany | Boehringer Ingelheim Investigational Site | Apolda | |
| Germany | Boehringer Ingelheim Investigational Site | Artern | |
| Germany | Boehringer Ingelheim Investigational Site | Aschersleben | |
| Germany | Boehringer Ingelheim Investigational Site | Aub | |
| Germany | Boehringer Ingelheim Investigational Site | Babenhausen | |
| Germany | Boehringer Ingelheim Investigational Site | Bad Bevensen | |
| Germany | Boehringer Ingelheim Investigational Site | Bad Buchau | |
| Germany | Boehringer Ingelheim Investigational Site | Bad Essen | |
| Germany | Boehringer Ingelheim Investigational Site | Bad Krozingen | |
| Germany | Boehringer Ingelheim Investigational Site | Bad Laasphe | |
| Germany | Boehringer Ingelheim Investigational Site | Bad Langensalza | |
| Germany | Boehringer Ingelheim Investigational Site | Bad Schussenried | |
| Germany | Boehringer Ingelheim Investigational Site | Bautzen | |
| Germany | Boehringer Ingelheim Investigational Site | Bergholz-Rehbrücke | |
| Germany | Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | Boehringer Ingelheim Investigational Site | Bernburg | |
| Germany | Boehringer Ingelheim Investigational Site | Bernsdorf | |
| Germany | Boehringer Ingelheim Investigational Site | Bevern | |
| Germany | Boehringer Ingelheim Investigational Site | Biberach | |
| Germany | Boehringer Ingelheim Investigational Site | Bienenbüttel | |
| Germany | Boehringer Ingelheim Investigational Site | Birkenwerder | |
| Germany | Boehringer Ingelheim Investigational Site | Bisingen | |
| Germany | Boehringer Ingelheim Investigational Site | Bodelshausen | |
| Germany | Boehringer Ingelheim Investigational Site | Bodenwöhr | |
| Germany | Boehringer Ingelheim Investigational Site | Bornheim | |
| Germany | Boehringer Ingelheim Investigational Site | Braunschweig | |
| Germany | Boehringer Ingelheim Investigational Site | Bremen | |
| Germany | Boehringer Ingelheim Investigational Site | Bückeburg | |
| Germany | Boehringer Ingelheim Investigational Site | Buckenhof | |
| Germany | Boehringer Ingelheim Investigational Site | Büdelsdorf | |
| Germany | Boehringer Ingelheim Investigational Site | Bünde | |
| Germany | Boehringer Ingelheim Investigational Site | Burgdorf | |
| Germany | Boehringer Ingelheim Investigational Site | Burgheim | |
| Germany | Boehringer Ingelheim Investigational Site | Burgoberbach | |
| Germany | Boehringer Ingelheim Investigational Site | Calbe | |
| Germany | Boehringer Ingelheim Investigational Site | Calw | |
| Germany | Boehringer Ingelheim Investigational Site | Castrop-Rauxel | |
| Germany | Boehringer Ingelheim Investigational Site | Celle | |
| Germany | Boehringer Ingelheim Investigational Site | Chemnitz | |
| Germany | Boehringer Ingelheim Investigational Site | Coppenbrügge | |
| Germany | Boehringer Ingelheim Investigational Site | Cottbus | |
| Germany | Boehringer Ingelheim Investigational Site | Cuxhaven | |
| Germany | Boehringer Ingelheim Investigational Site | Dänischenhagen | |
| Germany | Boehringer Ingelheim Investigational Site | Daun | |
| Germany | Boehringer Ingelheim Investigational Site | Delligsen | |
| Germany | Boehringer Ingelheim Investigational Site | Denkendorf | |
| Germany | Boehringer Ingelheim Investigational Site | Dillingen | |
| Germany | Boehringer Ingelheim Investigational Site | Donauwörth | |
| Germany | Boehringer Ingelheim Investigational Site | Dörentrup | |
| Germany | Boehringer Ingelheim Investigational Site | Dormagen | |
| Germany | Boehringer Ingelheim Investigational Site | Dorn-Dürkheim | |
| Germany | Boehringer Ingelheim Investigational Site | Dortmund | |
| Germany | Boehringer Ingelheim Investigational Site | Dreieich | |
| Germany | Boehringer Ingelheim Investigational Site | Dresden | |
| Germany | Boehringer Ingelheim Investigational Site | Duisburg | |
| Germany | Boehringer Ingelheim Investigational Site | Düren | |
| Germany | Boehringer Ingelheim Investigational Site | Düsseldorf | |
| Germany | Boehringer Ingelheim Investigational Site | Edenkoben | |
| Germany | Boehringer Ingelheim Investigational Site | Eisingen | |
| Germany | Boehringer Ingelheim Investigational Site | Elsenfeld | |
| Germany | Boehringer Ingelheim Investigational Site | Emsdetten | |
| Germany | Boehringer Ingelheim Investigational Site | Eppelheim | |
| Germany | Boehringer Ingelheim Investigational Site | Erftstadt | |
| Germany | Boehringer Ingelheim Investigational Site | Erfurt | |
| Germany | Boehringer Ingelheim Investigational Site | Erlangen | |
| Germany | Boehringer Ingelheim Investigational Site | Erndtebrück | |
| Germany | Boehringer Ingelheim Investigational Site | Eschau | |
| Germany | Boehringer Ingelheim Investigational Site | Essen | |
| Germany | Boehringer Ingelheim Investigational Site | Esslingen | |
| Germany | Boehringer Ingelheim Investigational Site | Eutin | |
| Germany | Boehringer Ingelheim Investigational Site | Extertal | |
| Germany | Boehringer Ingelheim Investigational Site | Falkensee | |
| Germany | Boehringer Ingelheim Investigational Site | Frankfurt | |
| Germany | Boehringer Ingelheim Investigational Site | Freiburg | |
| Germany | Boehringer Ingelheim Investigational Site | Freising | |
| Germany | Boehringer Ingelheim Investigational Site | Friedenfels | |
| Germany | Boehringer Ingelheim Investigational Site | Friedrichsthal | |
| Germany | Boehringer Ingelheim Investigational Site | Fulda | |
| Germany | Boehringer Ingelheim Investigational Site | Fürstenwalde | |
| Germany | Boehringer Ingelheim Investigational Site | Geiselhöring | |
| Germany | Boehringer Ingelheim Investigational Site | Gelsenkirchen | |
| Germany | Boehringer Ingelheim Investigational Site | Gensingen | |
| Germany | Boehringer Ingelheim Investigational Site | Germering | |
| Germany | Boehringer Ingelheim Investigational Site | Gladbeck | |
| Germany | Boehringer Ingelheim Investigational Site | Glashütten | |
| Germany | Boehringer Ingelheim Investigational Site | Göttingen | |
| Germany | Boehringer Ingelheim Investigational Site | Greiz | |
| Germany | Boehringer Ingelheim Investigational Site | Grömitz | |
| Germany | Boehringer Ingelheim Investigational Site | Großenkneten | |
| Germany | Boehringer Ingelheim Investigational Site | Großenlüder | |
| Germany | Boehringer Ingelheim Investigational Site | Haag | |
| Germany | Boehringer Ingelheim Investigational Site | Hagen | |
| Germany | Boehringer Ingelheim Investigational Site | Halle | |
| Germany | Boehringer Ingelheim Investigational Site | Haltern | |
| Germany | Boehringer Ingelheim Investigational Site | Hamburg | |
| Germany | Boehringer Ingelheim Investigational Site | Hamminkeln | |
| Germany | Boehringer Ingelheim Investigational Site | Hanerau-Hademarschen | |
| Germany | Boehringer Ingelheim Investigational Site | Hannover | |
| Germany | Boehringer Ingelheim Investigational Site | Harsewinkel | |
| Germany | Boehringer Ingelheim Investigational Site | Hartenstein | |
| Germany | Boehringer Ingelheim Investigational Site | Hattorf | |
| Germany | Boehringer Ingelheim Investigational Site | Heilbronn | |
| Germany | Boehringer Ingelheim Investigational Site | Heinsberg | |
| Germany | Boehringer Ingelheim Investigational Site | Herbertshofen | |
| Germany | Boehringer Ingelheim Investigational Site | Herbrechtingen | |
| Germany | Boehringer Ingelheim Investigational Site | Hermsdorf | |
| Germany | Boehringer Ingelheim Investigational Site | Hohenhameln | |
| Germany | Boehringer Ingelheim Investigational Site | Hosena | |
| Germany | Boehringer Ingelheim Investigational Site | Hude | |
| Germany | Boehringer Ingelheim Investigational Site | Ippesheim | |
| Germany | Boehringer Ingelheim Investigational Site | Ispringen | |
| Germany | Boehringer Ingelheim Investigational Site | Jahnsdorf | |
| Germany | Boehringer Ingelheim Investigational Site | Jever | |
| Germany | Boehringer Ingelheim Investigational Site | Jühnde | |
| Germany | Boehringer Ingelheim Investigational Site | Jünkerath | |
| Germany | Boehringer Ingelheim Investigational Site | Kahl | |
| Germany | Boehringer Ingelheim Investigational Site | Kalbach | |
| Germany | Boehringer Ingelheim Investigational Site | Kamen | |
| Germany | Boehringer Ingelheim Investigational Site | Kassel | |
| Germany | Boehringer Ingelheim Investigational Site | Katzhütte | |
| Germany | Boehringer Ingelheim Investigational Site | Kaufbeuren | |
| Germany | Boehringer Ingelheim Investigational Site | Kirchardt | |
| Germany | Boehringer Ingelheim Investigational Site | Kirchheim | |
| Germany | Boehringer Ingelheim Investigational Site | Kirchlengern | |
| Germany | Boehringer Ingelheim Investigational Site | Kitzingen | |
| Germany | Boehringer Ingelheim Investigational Site | Köln | |
| Germany | Boehringer Ingelheim Investigational Site | Kressbronn | |
| Germany | Boehringer Ingelheim Investigational Site | Kronach | |
| Germany | Boehringer Ingelheim Investigational Site | Kropp | |
| Germany | Boehringer Ingelheim Investigational Site | Krumbach | |
| Germany | Boehringer Ingelheim Investigational Site | Kuppenheim | |
| Germany | Boehringer Ingelheim Investigational Site | Laatzen | |
| Germany | Boehringer Ingelheim Investigational Site | Lahnau | |
| Germany | Boehringer Ingelheim Investigational Site | Lahr | |
| Germany | Boehringer Ingelheim Investigational Site | Lampertheim | |
| Germany | Boehringer Ingelheim Investigational Site | Langen | |
| Germany | Boehringer Ingelheim Investigational Site | Langenfeld | |
| Germany | Boehringer Ingelheim Investigational Site | Lauf | |
| Germany | Boehringer Ingelheim Investigational Site | Leer | |
| Germany | Boehringer Ingelheim Investigational Site | Lehrberg | |
| Germany | Boehringer Ingelheim Investigational Site | Leipzig | |
| Germany | Boehringer Ingelheim Investigational Site | Lengefeld | |
| Germany | Boehringer Ingelheim Investigational Site | Leonberg | |
| Germany | Boehringer Ingelheim Investigational Site | Leverkusen | |
| Germany | Boehringer Ingelheim Investigational Site | Lienen | |
| Germany | Boehringer Ingelheim Investigational Site | Lohfelden | |
| Germany | Boehringer Ingelheim Investigational Site | Lohra | |
| Germany | Boehringer Ingelheim Investigational Site | Lüderitz | |
| Germany | Boehringer Ingelheim Investigational Site | Ludwigshafen | |
| Germany | Boehringer Ingelheim Investigational Site | Lunzenau | |
| Germany | Boehringer Ingelheim Investigational Site | Lütjenburg | |
| Germany | Boehringer Ingelheim Investigational Site | Magdeburg | |
| Germany | Boehringer Ingelheim Investigational Site | Mannheim | |
| Germany | Boehringer Ingelheim Investigational Site | Marburg | |
| Germany | Boehringer Ingelheim Investigational Site | Meerbusch | |
| Germany | Boehringer Ingelheim Investigational Site | Meldorf | |
| Germany | Boehringer Ingelheim Investigational Site | Mendig | |
| Germany | Boehringer Ingelheim Investigational Site | Mengkofen | |
| Germany | Boehringer Ingelheim Investigational Site | Meßstetten | |
| Germany | Boehringer Ingelheim Investigational Site | Mindelheim | |
| Germany | Boehringer Ingelheim Investigational Site | Mittweida | |
| Germany | Boehringer Ingelheim Investigational Site | Mönchengladbach | |
| Germany | Boehringer Ingelheim Investigational Site | Moosburg | |
| Germany | Boehringer Ingelheim Investigational Site | Mosbach | |
| Germany | Boehringer Ingelheim Investigational Site | Mühlhausen | |
| Germany | Boehringer Ingelheim Investigational Site | Mülheim | |
| Germany | Boehringer Ingelheim Investigational Site | München | |
| Germany | Boehringer Ingelheim Investigational Site | Niederndodeleben | |
| Germany | Boehringer Ingelheim Investigational Site | Nienburg | |
| Germany | Boehringer Ingelheim Investigational Site | Nürnberg | |
| Germany | Boehringer Ingelheim Investigational Site | Oberdorla | |
| Germany | Boehringer Ingelheim Investigational Site | Oberursel | |
| Germany | Boehringer Ingelheim Investigational Site | Oer-Erkenschwick | |
| Germany | Boehringer Ingelheim Investigational Site | Olbernhau | |
| Germany | Boehringer Ingelheim Investigational Site | Olfen | |
| Germany | Boehringer Ingelheim Investigational Site | Osnabrück | |
| Germany | Boehringer Ingelheim Investigational Site | Ostrach | |
| Germany | Boehringer Ingelheim Investigational Site | Parey | |
| Germany | Boehringer Ingelheim Investigational Site | Petershagen | |
| Germany | Boehringer Ingelheim Investigational Site | Pirmasens | |
| Germany | Boehringer Ingelheim Investigational Site | Plattling | |
| Germany | Boehringer Ingelheim Investigational Site | Pleidelsheim | |
| Germany | Boehringer Ingelheim Investigational Site | Potsdam | |
| Germany | Boehringer Ingelheim Investigational Site | Pulheim | |
| Germany | Boehringer Ingelheim Investigational Site | Rastede | |
| Germany | Boehringer Ingelheim Investigational Site | Remscheid | |
| Germany | Boehringer Ingelheim Investigational Site | Rhaunen | |
| Germany | Boehringer Ingelheim Investigational Site | Roggendorf | |
| Germany | Boehringer Ingelheim Investigational Site | Rossau | |
| Germany | Boehringer Ingelheim Investigational Site | Rostock | |
| Germany | Boehringer Ingelheim Investigational Site | Röthenbach | |
| Germany | Boehringer Ingelheim Investigational Site | Saerbeck | |
| Germany | Boehringer Ingelheim Investigational Site | Schönau | |
| Germany | Boehringer Ingelheim Investigational Site | Schönebeck | |
| Germany | Boehringer Ingelheim Investigational Site | Schorndorf | |
| Germany | Boehringer Ingelheim Investigational Site | Schwäbisch Gmünd | |
| Germany | Boehringer Ingelheim Investigational Site | Schwarzenbach a Wald | |
| Germany | Boehringer Ingelheim Investigational Site | Schwerte | |
| Germany | Boehringer Ingelheim Investigational Site | Seelow | |
| Germany | Boehringer Ingelheim Investigational Site | Selfkant | |
| Germany | Boehringer Ingelheim Investigational Site | Senftenberg | |
| Germany | Boehringer Ingelheim Investigational Site | Siegen | |
| Germany | Boehringer Ingelheim Investigational Site | Sögel | |
| Germany | Boehringer Ingelheim Investigational Site | Solingen | |
| Germany | Boehringer Ingelheim Investigational Site | Sonsbeck | |
| Germany | Boehringer Ingelheim Investigational Site | Speyer | |
| Germany | Boehringer Ingelheim Investigational Site | Sprendlingen | |
| Germany | Boehringer Ingelheim Investigational Site | Stadland | |
| Germany | Boehringer Ingelheim Investigational Site | Stadthagen | |
| Germany | Boehringer Ingelheim Investigational Site | Straubing | |
| Germany | Boehringer Ingelheim Investigational Site | Stuhr | |
| Germany | Boehringer Ingelheim Investigational Site | Stutensee | |
| Germany | Boehringer Ingelheim Investigational Site | Stuttgart | |
| Germany | Boehringer Ingelheim Investigational Site | Suhl | |
| Germany | Boehringer Ingelheim Investigational Site | Sulzbach | |
| Germany | Boehringer Ingelheim Investigational Site | Sulzbach-Rosenberg | |
| Germany | Boehringer Ingelheim Investigational Site | Teterow | |
| Germany | Boehringer Ingelheim Investigational Site | Tettnang | |
| Germany | Boehringer Ingelheim Investigational Site | Thaleischweiler-Fröschen | |
| Germany | Boehringer Ingelheim Investigational Site | Troisdorf | |
| Germany | Boehringer Ingelheim Investigational Site | Veilsdorf | |
| Germany | Boehringer Ingelheim Investigational Site | Vellahn | |
| Germany | Boehringer Ingelheim Investigational Site | Viernheim | |
| Germany | Boehringer Ingelheim Investigational Site | Villingen-Schwenningen | |
| Germany | Boehringer Ingelheim Investigational Site | Waghäusel | |
| Germany | Boehringer Ingelheim Investigational Site | Wehrsdorf | |
| Germany | Boehringer Ingelheim Investigational Site | Weibern | |
| Germany | Boehringer Ingelheim Investigational Site | Weimar | |
| Germany | Boehringer Ingelheim Investigational Site | Welzheim | |
| Germany | Boehringer Ingelheim Investigational Site | Wemding | |
| Germany | Boehringer Ingelheim Investigational Site | Wertingen | |
| Germany | Boehringer Ingelheim Investigational Site | Wesel | |
| Germany | Boehringer Ingelheim Investigational Site | Wesseling | |
| Germany | Boehringer Ingelheim Investigational Site | Wetzendorf | |
| Germany | Boehringer Ingelheim Investigational Site | Wetzlar | |
| Germany | Boehringer Ingelheim Investigational Site | Wickede | |
| Germany | Boehringer Ingelheim Investigational Site | Wiesbaden | |
| Germany | Boehringer Ingelheim Investigational Site | Winsen | |
| Germany | Boehringer Ingelheim Investigational Site | Wöbbelin | |
| Germany | Boehringer Ingelheim Investigational Site | Zschocken | |
| Germany | Boehringer Ingelheim Investigational Site | Zschopau | |
| Germany | Boehringer Ingelheim Investigational Site | Zweibrücken | |
| Germany | Boehringer Ingelheim Investigational Site | Zwickau |
| Lead Sponsor | Collaborator |
|---|---|
| Boehringer Ingelheim |
Germany,
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04786314 -
The Effect of Hot and Cold Water Application on Pregnant Women With Restless Leg Syndrome
|
N/A | |
| Completed |
NCT01455012 -
Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrome
|
Phase 4 | |
| Terminated |
NCT01192503 -
Safety and Efficacy of Rasagiline in Restless Legs Syndrome
|
Phase 2/Phase 3 | |
| Completed |
NCT00721279 -
Sifrol (Pramipexole) Onset of Action and Impact: a 12-weeks Observational Study in Patients With Primary Restless Legs Syndrome
|
N/A | |
| Completed |
NCT00530530 -
ASP8825 - Study in Patients With Restless Legs Syndrome
|
Phase 2 | |
| Completed |
NCT00942253 -
Exercise Training in Dialysis Patients With Restless Legs Syndrome (RLS)
|
Phase 2 | |
| Completed |
NCT00375284 -
A 6 Week Trial to Study the Efficacy and Safety of a Starting Dose 0.25 mg Pramipexole (Mirapex) in Patients With RLS
|
Phase 4 | |
| Completed |
NCT00479531 -
Sequential Compression Devices for Treatment of Restless Legs Syndrome
|
Phase 3 | |
| Recruiting |
NCT05581576 -
Pitolisant in Refractory Restless Legs Syndrome
|
Phase 4 | |
| Active, not recruiting |
NCT03218969 -
Treatment of Restless Leg Syndrome (RLS) Augmentation With Ecopipam, a D1 Specific Antagonist
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04144790 -
Impact of Iron Supplementation Treatment on Brain Iron Concentrations
|
||
| Completed |
NCT05787080 -
Massage, Oxidative and Antioxidant Enzymes in Hemodialysis Patients With Restless Legs Syndrome(RLS)
|
N/A | |
| Not yet recruiting |
NCT05529095 -
Sublingual Apomorphine in Refractory Restless Legs Syndrome
|
Phase 4 | |
| Recruiting |
NCT05044520 -
Clinical Features Associated With Restless Legs Syndrome.
|
||
| Withdrawn |
NCT03849001 -
Impact of Acute Leg Cycling at Various Intensities on RLS Severity in Persons With MS
|
N/A | |
| Completed |
NCT03076541 -
Cardiovascular Variability, Heart Rate Response, and Electromyogram Power Associated With Periodic Leg Movements.
|
N/A | |
| Recruiting |
NCT04145674 -
A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo
|
Phase 2 | |
| Completed |
NCT02532608 -
Infra-slow Oscillations During Sleep
|
N/A | |
| Completed |
NCT01528462 -
Sleep Disorders Managed and Assessed Rapidly in Transient Ischemic Attack (TIA) and In Early Stroke
|
||
| Completed |
NCT00748098 -
Polysomnography Study of GSK1838262 Extended Release Tablets Versus Placebo in RLS and Associated Sleep Disturbance
|
Phase 3 |