Healthy Subjects Clinical Trial
Official title:
Infra-slow Oscillations During Sleep, After Acute Sleep Deprivation and in Subjects With Restless Legs Syndrome/Periodic Leg Movements During Sleep (RLS/PLMS): an Explorative, Prospective, Monocentric, Observational Case-control and Interventional Study
In this study the investigators plan to systematically characterise infra-slow EEG oscillations during sleep, explore their relationship to the microstructure of sleep, and investigate its role in the physiology and pathophysiology of sleep by co-registration of Full band EEG with polysomnography during wake and sleep in healthy subjects, after sleep deprivation, and in patients with restless legs syndrome/periodic leg movements during sleep (RLS/PLMS).
Sleep is a highly dynamic process and during large parts of sleep the level of arousal
fluctuates on a multi-second time scale between the sleep stage specific background and
transient, phasic events that clearly arise from this background and constitute the
microstructure of sleep. This microstructure is part of the dynamic physiological sleep
regulation and at the same time reflects the instability of sleep, is critically involved in
the pathophysiology of sleep and a determinant of the recuperative value of sleep and daytime
performance.
Intriguingly, these sleep microstructural fluctuations are in a multi-second range that
corresponds closely to the so-called infra-slow oscillations that are ubiquitous in the
central nervous system. Infra-slow oscillations (0.01 - 0.1 Hz) have been observed in both
humans and animals across brain structures and spatial scales in the dynamics of single unit
firing rates, direct electrical potential fluctuations and oscillation amplitude modulations.
The possibility to record these infra-slow oscillations on the level of the surface EEG with
direct current (DC) or Full band (Fb) EEG offers a new approach to study the microstructure
of sleep and characterise the full range of sleep-related EEG oscillations.
The objectives of this study are:
1. to record and systematically characterise infra-slow oscillations during wake and all
stages of sleep
2. to explore the relationship between sleep infra-slow oscillations and microstructural
events of sleep, in particular the cyclic alternating pattern
3. to explore the effect of acute sleep deprivation on sleep infra-slow EEG activity
4. to investigate infra-slow sleep EEG activity in patients with RLS/PLMS, common sleep
disorders with prominent periodic arousals, heart rate activations, and leg movements
5. to explore the relationship between infra-slow EEG oscillations and periodic events in
movement and autonomic system activity in patients with RLS/PLMS.
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