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Resting Energy Expenditure clinical trials

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NCT ID: NCT05990387 Recruiting - Clinical trials for Brown Adipose Tissue

MIrabegron and Physiological Function in Cold Environments

Start date: July 19, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal discomfort is subjectively reported by many Navy divers. Brown adipose tissue is highly thermogenic in humans. Therefore, activation of brown adipose tissue might improve cold water tolerance and lower thermal discomfort during cold water diving operations. Mirabegron is a beta-3-adrenergic receptor agonist that is used to treat overactive bladder. Beta-3-adrenergic receptors are located on the urinary bladder, gallbladder and brown adipose tissue. Recent evidence has demonstrated that acute mirabegron administration increases thermogenesis for ~3 hours in humans. However, it is currently not known which dose of mirabegron can increase thermogenesis for longer durations. It is also not known if mirabegron administration can improve cold water tolerance and thermal discomfort during cold water immersion. Finally, it is not known if mirabegron can increase thermogenesis during sympathetic stimulation. This project will fill these knowledge gaps by determining if acute mirabegron administration will delay the fall in core temperature and the onset of shivering during a progressive cold-water immersion challenge. This study is part of a collection of studies that will show if mirabegron is a potential ergogenic aid that can be used to improve cold water tolerance in Navy divers which will ultimately improve the likelihood of successful missions.

NCT ID: NCT05711212 Recruiting - Clinical trials for Resting Energy Expenditure

Effects of Xanthohumol on Resting Energy Expenditure and Substrate Oxidation in Healthy Women

Start date: February 15, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effects of Xanthohumol on resting energy expenditure and substrate oxidation in healthy women. It is assumed that resting energy expenditure and fatty acid oxidation is higher after Xanthohumol ingestion.

NCT ID: NCT05505240 Completed - Clinical trials for Resting Energy Expenditure

Influence of Ambient Temperature on Resting Energy Expenditure of Healthy Adults

Start date: November 21, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the influence of four different ambient temperatures (18, 22, 28, 38°C) on the resting energy expenditure of healthy adults by respiratory gas analysis. It is assumed that the resting energy expenditure is higher at 18°C and 38°C than at the temperatures in between.

NCT ID: NCT04947839 Completed - Peritoneal Dialysis Clinical Trials

Novel Equation for Estimating Resting Energy Expenditure in Dialysis Patients

Start date: March 18, 2021
Phase:
Study type: Observational

The energy and nutrition states are closely associated with dialysis patients' complications and outcomes. To reach the energy balance target, we need the accurate resting energy expenditure level of patients. Traditional equations do not focus on and applicable to peritoneal dialysis patients, so we aim to develop and validate an equation for estimating resting energy expenditure in peritoneal patients.

NCT ID: NCT04766021 Completed - Clinical trials for Brown Adipose Tissue

Mirabegron and Physiological Function in Cold Environments

Start date: November 30, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal discomfort is subjectively reported by many Navy divers. Brown adipose tissue is highly thermogenic in humans. Therefore, activation of brown adipose tissue might improve cold water tolerance and lower thermal discomfort during cold water diving operations. Mirabegron is a beta-3-adrenergic receptor agonist that is used to treat overactive bladder. Beta-3-adrenergic receptors are located on the urinary bladder, gallbladder and brown adipose tissue. Recent evidence has demonstrated that acute mirabegron administration increases thermogenesis for ~3 hours in humans. However, it is currently not known which dose of mirabegron can increase thermogenesis for longer durations. It is also not known if mirabegron administration can improve cold water tolerance and thermal discomfort during cold water immersion. Finally, it is not known if mirabegron can increase thermogenesis during sympathetic stimulation. This project will fill these knowledge gaps by determining which dose of mirabegron administration will increase thermogenesis during 6 hours of a mild cold stress challenge. This study is part of a collection of studies that will show if mirabegron is a potential ergogenic aid that can be used to improve cold water tolerance in Navy divers which will ultimately improve the likelihood of successful missions.

NCT ID: NCT04500483 Recruiting - Critical Illness Clinical Trials

Indirect Calorimetry in Patients at Risk of Malnutrition

Start date: August 15, 2020
Phase:
Study type: Observational

Burn patients treated in an outpatient clinic and ICU survivors are at risk of malnutrition. There are no clear guidelines determining the energy target in those two populations. The aim of this observation study is to measure the resting energy expenditure of those patients, using indirect calorimetry.

NCT ID: NCT04474587 Suspended - Clinical trials for Resting Energy Expenditure

Resting Energy Expenditure in Patients With OHS Treated With Long-term NIV

Start date: September 1, 2020
Phase:
Study type: Observational

This study aims to compare, in subjects with obesity-hypoventilation syndrome (OHS) treated by long-term non-invasive ventilation (NIV), resting energy expenditure (REE) in spontaneous breathing and under NIV. The hypothesise of this study is that REE will be lower under NIV than under spontaneous breathing.

NCT ID: NCT03569852 Completed - Clinical trials for Cardiovascular Risk Factor

Time Restricted Feeding in Male Runners

Start date: July 15, 2018
Phase: N/A
Study type: Interventional

This is a cross-over intervention study designed to evaluate how four weeks of time restricted feeding (16 hours fasting and 8 hours feeding), compared to four weeks of a more traditional eating pattern (12 hours fasting and 12 hours feeding), affects resting energy expenditure, subjective and biochemical markers of satiety and hunger, body composition, cardiovascular health, substrate utilization and fitness in male competitive runners.

NCT ID: NCT03511950 Recruiting - Nutrition Clinical Trials

The Relationship Between the Change of Resting Energy Expenditure and Nutritional Status .

Start date: April 1, 2021
Phase:
Study type: Observational

Peritonitis is a common and devastating complication in patients on peritoneal dialysis (PD). It is a known fact that persistent inflammatory state and nutritional deterioration are closely associated with increased mortality in PD patients.And resting energy expenditure(REE) is significantly increased in acute and chronic inflammation in patients with chronic kidney disease (including dialysis patients).However,it is limited to the changing trend and duration of REE in peritonitis.Investigators hypothesize that the increase in total energy consumption resulting from the increase of REE which may accompany with decreased energy intake will lead to negative energy balance and nutritional deterioration, which may affect the prognosis of patients.Therefore,a prospective cohort study will be designed to dynamically research the change of REE accompanied with the nutrition status in peritonitis and provide the basis for peritonitis management in the future.

NCT ID: NCT03377413 Completed - Clinical trials for Chronic Kidney Disease

Novel Equation for Estimating Resting Energy Expenditure

Start date: December 14, 2017
Phase:
Study type: Observational

The energy and nutrition states are closely associated with CKD patients complications and outcomes.To reach the energy balance target, we need the accurate resting energy expenditure level of patients. Traditional equations are not applicable to CKD patients,so we aim to develop and validate a equation for estimating resting energy expenditure in CKD patients.