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Resting Energy Expenditure clinical trials

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NCT ID: NCT05990387 Completed - Clinical trials for Brown Adipose Tissue

MIrabegron and Physiological Function in Cold Environments

Start date: July 19, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal discomfort is subjectively reported by many Navy divers. Brown adipose tissue is highly thermogenic in humans. Therefore, activation of brown adipose tissue might improve cold water tolerance and lower thermal discomfort during cold water diving operations. Mirabegron is a beta-3-adrenergic receptor agonist that is used to treat overactive bladder. Beta-3-adrenergic receptors are located on the urinary bladder, gallbladder and brown adipose tissue. Recent evidence has demonstrated that acute mirabegron administration increases thermogenesis for ~3 hours in humans. However, it is currently not known which dose of mirabegron can increase thermogenesis for longer durations. It is also not known if mirabegron administration can improve cold water tolerance and thermal discomfort during cold water immersion. Finally, it is not known if mirabegron can increase thermogenesis during sympathetic stimulation. This project will fill these knowledge gaps by determining if acute mirabegron administration will delay the fall in core temperature and the onset of shivering during a progressive cold-water immersion challenge. This study is part of a collection of studies that will show if mirabegron is a potential ergogenic aid that can be used to improve cold water tolerance in Navy divers which will ultimately improve the likelihood of successful missions.

NCT ID: NCT05505240 Completed - Clinical trials for Resting Energy Expenditure

Influence of Ambient Temperature on Resting Energy Expenditure of Healthy Adults

Start date: November 21, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the influence of four different ambient temperatures (18, 22, 28, 38°C) on the resting energy expenditure of healthy adults by respiratory gas analysis. It is assumed that the resting energy expenditure is higher at 18°C and 38°C than at the temperatures in between.

NCT ID: NCT04947839 Completed - Peritoneal Dialysis Clinical Trials

Novel Equation for Estimating Resting Energy Expenditure in Dialysis Patients

Start date: March 18, 2021
Phase:
Study type: Observational

The energy and nutrition states are closely associated with dialysis patients' complications and outcomes. To reach the energy balance target, we need the accurate resting energy expenditure level of patients. Traditional equations do not focus on and applicable to peritoneal dialysis patients, so we aim to develop and validate an equation for estimating resting energy expenditure in peritoneal patients.

NCT ID: NCT04766021 Completed - Clinical trials for Brown Adipose Tissue

Mirabegron and Physiological Function in Cold Environments

Start date: November 30, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal discomfort is subjectively reported by many Navy divers. Brown adipose tissue is highly thermogenic in humans. Therefore, activation of brown adipose tissue might improve cold water tolerance and lower thermal discomfort during cold water diving operations. Mirabegron is a beta-3-adrenergic receptor agonist that is used to treat overactive bladder. Beta-3-adrenergic receptors are located on the urinary bladder, gallbladder and brown adipose tissue. Recent evidence has demonstrated that acute mirabegron administration increases thermogenesis for ~3 hours in humans. However, it is currently not known which dose of mirabegron can increase thermogenesis for longer durations. It is also not known if mirabegron administration can improve cold water tolerance and thermal discomfort during cold water immersion. Finally, it is not known if mirabegron can increase thermogenesis during sympathetic stimulation. This project will fill these knowledge gaps by determining which dose of mirabegron administration will increase thermogenesis during 6 hours of a mild cold stress challenge. This study is part of a collection of studies that will show if mirabegron is a potential ergogenic aid that can be used to improve cold water tolerance in Navy divers which will ultimately improve the likelihood of successful missions.

NCT ID: NCT03569852 Completed - Clinical trials for Cardiovascular Risk Factor

Time Restricted Feeding in Male Runners

Start date: July 15, 2018
Phase: N/A
Study type: Interventional

This is a cross-over intervention study designed to evaluate how four weeks of time restricted feeding (16 hours fasting and 8 hours feeding), compared to four weeks of a more traditional eating pattern (12 hours fasting and 12 hours feeding), affects resting energy expenditure, subjective and biochemical markers of satiety and hunger, body composition, cardiovascular health, substrate utilization and fitness in male competitive runners.

NCT ID: NCT03377413 Completed - Clinical trials for Chronic Kidney Disease

Novel Equation for Estimating Resting Energy Expenditure

Start date: December 14, 2017
Phase:
Study type: Observational

The energy and nutrition states are closely associated with CKD patients complications and outcomes.To reach the energy balance target, we need the accurate resting energy expenditure level of patients. Traditional equations are not applicable to CKD patients,so we aim to develop and validate a equation for estimating resting energy expenditure in CKD patients.

NCT ID: NCT03219229 Completed - Clinical trials for Resting Energy Expenditure

Metabolic Effects of Differential Organ Growth Rates

Start date: February 14, 2004
Phase: N/A
Study type: Observational

Young children have a high resting energy expenditure (REE) relative to their body weight and metabolically active compartment, fat-free mass (FFM). Both body weight and FFM are, however, metabolically heterogeneous and include organs and tissues varying widely in specific metabolic rate (i.e., organ REE/kg/d). One prevailing hypothesis is that most, if not all, of the higher REE observed in young animals and children compared to adults can be accounted for by a larger proportion of high metabolic rate components such as brain, liver, and heart..

NCT ID: NCT03193632 Completed - Clinical trials for Resting Energy Expenditure

Predicting Resting Energy Expenditure in Critically Ill Patients by Measuring Lean Body Mass by US

Start date: July 1, 2017
Phase:
Study type: Observational

The study aims to correlate Lean Body Mass (LBM) Evaluated by Musculoskeletal Ultrasound with Resting Energy Expenditure (REE) measured by Indirect Calorimetry and to generate a predictive equation of REE based on LBM, in addition to identifying other factors that may affect REE such as age, gender, and severity scores.

NCT ID: NCT01595191 Completed - Clinical trials for Resting Energy Expenditure

Bach Music in Preterm Infants: No "Mozart Effect" on Resting Energy Expenditure

Start date: July 2010
Phase: N/A
Study type: Interventional

Exposure to Mozart music significantly lowers resting energy expenditure (REE) in healthy preterm infants. Whether this finding is related to music per-se or to music by Mozart is unknown. The objective is to study whether J.S. Bach music has a lowering effect on REE similar to that of Mozart music.