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Respiratory Tract Diseases clinical trials

View clinical trials related to Respiratory Tract Diseases.

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NCT ID: NCT03037385 Completed - Neoplasms Clinical Trials

Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors

ARROW
Start date: March 17, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in participants with medullary thyroid cancer (MTC), RET-altered NSCLC and other RET-altered solid tumors.

NCT ID: NCT02973282 Completed - Asthma Clinical Trials

Diagnosing Respiratory Disease in Children Using Cough Sounds

SMARTCOUGH-C
Start date: December 2016
Phase: N/A
Study type: Observational

The purpose of this prospective study is to evaluate the efficacy of the ResAppDx software application in diagnosis of pneumonia and other respiratory conditions (bronchiolitis, asthma/reactive airway disease, croup, upper or lower respiratory tract infections) in infants and children. Patient's cough sounds will be recorded using a smartphone and analysed using the ResAppDx software. The ResAppDx diagnosis will be compared to radiologic diagnosis and/or clinical diagnosis. The ResAppDx diagnosis will not be provided to the clinician or patient.

NCT ID: NCT02955108 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

The Effect of Distractive Auditory Stimuli (Music) on Dyspnea and Anxiety During Exercise in Adults With Chronic Respiratory Diseases

Start date: October 27, 2017
Phase: N/A
Study type: Interventional

The objective of this study is to look at the effects of distractive auditory stimuli (DAS) on reducing dyspnea intensity and related anxiety and increasing exercise tolerance. Investigators hope that compared to a no-music control condition, that under a music condition participants with COPD will (a) demonstrate increased self-paced walk distance and enjoyment; (b) have less dyspnea intensity, (c) experience less dyspnea anxiety; (d) have less fatigue and state anxiety; and (e) higher maximum heart rate. The upbeat music with a tempo of 90 - 100 bpm (an average-to-moderate walking tempo) is expected to have distractive and performance enhancing effects in order to increase tolerance to dyspnea and exercise. The long-term goal of this study is to increase physical activity in adults with COPD and RLD by promoting dyspnea and fatigue management through use of distractive auditory stimuli in the form of music.

NCT ID: NCT02950805 Completed - Clinical trials for Pulmonary/Respiratory Diseases

A Study to Assess the Effect of AZD5634 on Mucociliary Clearance, Safety, Tolerability and Pharmacokinetic Parameters in Patients With Cystic Fibrosis

Start date: May 30, 2017
Phase: Phase 1
Study type: Interventional

This study will assess the effect of inhaled AZD5634 on Mucociliary clearance (MCC) in patients with Cystic fibrosis (CF) after single-dose administration.

NCT ID: NCT02929524 Completed - Acute Pain Clinical Trials

Intranasal Ketamine as a Sedative for Venipuncture

Start date: April 2015
Phase: Phase 2/Phase 3
Study type: Interventional

Randomized clinical trial, controlled, double-blind, parallel two-arm.

NCT ID: NCT02898129 Completed - Clinical trials for Chronic Respiratory Diseases

Evaluating the Relationship Between Environmental Risk Factors in Housing Types and Chronic Respiratory Diseases in Ho Chi Minh City

Start date: September 2016
Phase: N/A
Study type: Interventional

The research question is "Are the different types of house in Ho Chi Minh city equally contributing to chronic respiratory diseases?". According to this question, a cross-sectional and explorative study was set up to explore the differences in the environmental characteristics and prevalence of chronic respiratory diseases among common housing types in Ho Chi Minh city. Preliminary work was performed in 100 houses (20 houses per type, included tube houses, rental houses, rural houses, slum and apartment) from November 2013 to June 2015. It included measures by environmental devices, questionnaires and indoor activities diaries. This study will aim to collect information about the prevalence of chronic respiratory diseases (CRDs) inside those house types to understand more about role of house types in developing CRDs. The objective is: 1. to evaluate the relationships between the type of house and lung function of inhabitants in each housing type. 2. to evaluate the effects of environmental risk factors in each house type on prevalence of CRDs

NCT ID: NCT02894190 Completed - Clinical trials for Chronic Respiratory Disease

Development and Validation of the BVQ

Start date: September 2016
Phase:
Study type: Observational

The main aim of this study is the development of the Beliefs about Ventilation Questionnaire (BVQ).

NCT ID: NCT02877121 Completed - Clinical trials for State Key Laboratory of Respiratory Disease

Respiratory Muscle Function and Neural Respiratory Drive in Interstitial Lung Disease

Start date: June 2016
Phase: N/A
Study type: Observational

The purpose of this study is to assess the Respiratory Muscle Function and Neural Respiratory Drive in Interstitial Lung Disease patients.

NCT ID: NCT02831751 Completed - Clinical trials for Respiratory Tract Infections

Immunogenicity, Safety, and Tolerability of a Plant-Derived Quadrivalent VLP Influenza Vaccine in Elderly Adults

Start date: April 2016
Phase: Phase 2
Study type: Interventional

This Phase 2 Quadrivalent VLP Vaccine study is intended to replicate and extend the immunogenicity and safety results obtained in earlier Phase 1-2 and Phase 2 studies. The study is being conducted to evaluate that the immunogenicity profile of the Quadrivalent VLP Vaccine meets the US Center for Biologics Evaluation and Research (CBER) licensure criteria and to evaluate if the immunogenicity and the safety profile of the Quadrivalent VLP Vaccine is acceptable and comparable to that of the FluLaval® Tetra and Fluzone® High-Dose (HD). The study will also help to define the optimal dose in this population, establish potential competitive advantages, and support the design of future studies.

NCT ID: NCT02817035 Completed - Clinical trials for State Key Laboratory of Respiratory Disease

Study of Neural Inspiratory Time and Expiratory Delay in Patient and Health During Spontaneous Breathing and Ventilation

Start date: June 2016
Phase: N/A
Study type: Interventional

To make these definitions of neural inspiratory time (Ti) and expiratory delay clearly.The present study was undertaken to examined the physiological signals of patients and healthy subjects during spontaneous breathing and noninvasive mechanical ventilation.