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Gas Exchange Derangement Physiopathology in Critically Ill Patients With COVID-19

Respiratory Failure Clinical Trial

Official title:
Gas Exchange Derangement Physiopathology and Response to Different Levels of Positive End-expiratory Pressure in Critically Ill Patients With COVID-19

Clinical Trial Summary

The study was designed to understand the pathophysiology of gas exchange derangement in critically ill patients with COVID-19. Specifically we will evaluate the effect of 3 different levels of positive end-expiratory pressure (PEEP) and two different levels of inspiratory oxygen fraction (FiO2) on gas exchange by analyzing shunt and dead space. Furthermore, complete respiratory mechanics and distribution of ventilation and perfusion by electrical impedance tomography will be assessed at each level of PEEP.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05132933
Study type Interventional
Source Policlinico Hospital
Contact
Status Completed
Phase N/A
Start date October 1, 2021
Completion date December 30, 2022
View Details
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