Respiratory Failure Clinical Trial
— RADAROfficial title:
Incidence, Risk Factors and Outcomes of Diaphragm Dysfunction After Lung Transplantation
NCT number | NCT04103996 |
Other study ID # | 19-5894 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | February 10, 2020 |
Est. completion date | December 31, 2021 |
Verified date | May 2024 |
Source | University Health Network, Toronto |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The study is designed to characterize the changes in diaphragm function after lung transplantation.
Status | Completed |
Enrollment | 15 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Adult patients greater than 18 years of age - Listed for lung transplantation Exclusion Criteria: - Known diagnosis of chronic neuromuscular disease - Relisting for transplantation - Bridging to lung transplantation with respiratory support |
Country | Name | City | State |
---|---|---|---|
Canada | Toronto General Hospital | Toronto |
Lead Sponsor | Collaborator |
---|---|
University Health Network, Toronto |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of diaphragm dysfunction at the first spontaneous breathing trial and at ICU discharge after lung transplantation | Diaphragm ultrasound will be used to visualize diaphragm dysfunction (maximal thickening fraction <20%) | First spontaneous breathing trial, an average of 1 to 7 days | |
Secondary | Pre-transplant diaphragm thickness and function compared to post-transplant diaphragm dysfunction | Diaphragm thickness and function documented on ultrasound will be assessed | 1 day |
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