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NCT04081155 Clinical Trial

Effect of PEEP on Lung Regional Ventilation and Perfusion

Respiratory Failure Clinical Trial

— PEEP  

Official title:
Effect of Positive End-expiratory Pressure(PEEP) on Regional Ventilation and Perfusion Estimated by Indicator-based Electrical Impedance Tomography(EIT) Method in Critically Ill Patients With Mechanical Ventilation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04081155
Other study ID # PEEP-lung perfusion
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2019
Est. completion date June 1, 2020

Study information
Verified date January 2019
Source Peking Union Medical College Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT

Description:

1. When the research team was available, adult patients within 7days who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study.

2. Written informed consent was obtained from all patients or next of kin before data were included in the study.

3. Information collected at enrollment included demographic characteristics, such as age, sex.

4. The blood pressure（BP）,heart rate（HR）, pulse O2（SpO2）,tidal volume and lung regional ventilation and perfusion were collected at PEEP 0 centimeter H2O column and PEEP 12-15 centimeter H2O column.

5. Indicator-based EIT method: rapidly inject 10ml 10% Sodium chloride（NaCL） through central venous catheter during a 8s respiratory hold, and the curve of impedence change was collected by EIT machine

Recruitment information / eligibility
Status Completed
Enrollment 33
Est. completion date June 1, 2020
Est. primary completion date May 28, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

1. have been placed central venous catheter based on patient's condition

2. Under mechanically ventilation

3. Under sedation and control ventilation mode

4. Year>18

Exclusion Criteria:

1. Pneumothorax

2. pregnancy

3. Severe chest wall wound

4. Severe hypernatremia

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
China Peking Union Medical College Hospital, Chinese Academy of Medical Science Beijing Beijing

Sponsors (1)
Lead Sponsor Collaborator
Yun Long

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary lung regional ventilation distribution lung regional ventilation distribution measured by EIT Hour 1
Primary lung regional perfusion distribution lung regional perfusion distribution measured by EIT Hour 1
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