Respiratory Failure Clinical Trial
Official title:
Impact of the Inspiratory Cortical Control on the Outcome of the Ventilatory Weaning Test in Patients Intubated in Resuscitation
In case of respiratory distress, patients are intubated to be connected to an artificial
respirator to ensure gas exchanges. Before any ventilatory weaning, a breathing test in
spontaneous ventilation under artificial nose is practiced. The patient keeps the
endotracheal tube but is no longer assisted by the ventilator. Mortality is markedly
increased with the prolongation of the weaning period. Despite the presence of all weaning
criteria and the success of a breathing test in spontaneous ventilation under artificial
nose, failure of extubation occurs in 20% of patients.
Experimental application of an additional inspiratory load in awake healthy subjects causes a
compensatory increase in respiratory work to maintain effective ventilation, and the subject
does not develop hypoventilation. This respiratory drive to breathe has been demonstrated by
quantified electroencephalography in inspiratory load tests in the form of pre-inspiratory
negative deflections of low amplitude similar to the potential described during the
preparation of the voluntary movement of a limb. These inspiratory pre-motor potentials begin
about 2.5 seconds before the start of a movement in the additional motor area.
Does the simple and noninvasive analysis of inspiratory cortical control during the
spontaneous ventilation breath test under artificial nose predict the outcome of this test as
well as weaning at 7 days?
n/a
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