Lung Volume Change Between Noninvasive Positive Pressure Ventilation by Nasal Pillow and High Flow Nasal Cannula

Respiratory Failure Clinical Trial

Official title:

The Difference of Lung Volume Change Detected by Electrical Impedance Tomography (EIT) Between Noninvasive Positive-pressure Ventilation (NIPPV) Support by Nasal Pillow and High Flow Nasal Cannula in Post-extubation Patients

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02292992
• Other study ID #: 14MMHIS167
• Status: Recruiting
• Phase: N/A
• First received: October 27, 2014
• Last updated: December 11, 2014
• Start date: December 2014
• Est. completion date: October 2015

Study information

• Verified date: December 2014
• Source: Mackay Memorial Hospital
• Contact: Kuo Li Kuo, MD
• Phone: +886975835135
• Email: lmn4093[@]gmail.com
• Is FDA regulated: No
• Health authority: Taiwan: Ministry of Health and Welfare
• Study type: Interventional

Clinical Trial Summary

The difference of lung volume change will be monitored by electrical impedance tomography before and after use of noninvasive positive pressure ventilation by nasal pillow and high flow nasal cannula in post-extubation patients.

Description:

Electrical impedance tomography can effectively monitor the lung volume change in ICU patients who were under mechanical ventilator or noninvasive positive pressure ventilator support. Continuous positive airway pressure (CPAP) support by nasal pillow and high flow nasal cannula can improve inspiratory function in extubated patients . However, the extent of lung volume change or functional residual volume (FRC) change by using these two devices were never surveyed before in extubated patients. The investigators will check end-expiratory lung volume (EELV) ,anterior, medio-anterior, medio-posterior and posterior EELV by electrical impedance tomography after use of these two devices in extubated patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: October 2015
• Est. primary completion date: October 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• >20 y/o

• Any extubated patients after tolerating spontaneous breathing trial

Exclusion Criteria:

• Presence of tracheostomy

• Recent facial trauma

• Active gastro-intestinal bleeding

• Do-not-intubate status and

• Planned use of BiPAP after extubation.

• Patients with unstable spinal lesions or fractures.

• BMI> 50

• Patients with a cardiac pacemaker

• Burn injury with skin defect

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Respiratory Failure
• Respiratory Insufficiency

Intervention

Device:
• Nasal Pillow CPAP
Nasal Pillow CPAP in extubated patients

Locations

Country	Name	City	State
Taiwan	Mackay Memorial Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
Mackay Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	• End-expiratory lung volume (EELV) determined by electrical impedance tomography after high flow nasal cannula and nasal pillow CPAP		at day 1	No
Secondary	Anterior, medio-anterior, medio-posterior and posterior EELV at each time		at day 1	No