PEEP Influence on Gas Exchange During Early Weaning

Respiratory Failure Clinical Trial

— MHOPEEP  

Official title:

The Influence of Different PEEP Values on Gas Exchange in Spontaneously Breathing Patients During Early Weaning

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT02281695
• Other study ID #: MHO 001
• Status: Withdrawn
• Phase: N/A
• Start date: October 2014
• Est. completion date: December 2018

Study information

• Verified date: August 2022
• Source: Marienhospital Osnabrück
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the differences in oxygenation and decarboxylation between two weaning processes.

Description:

First, during controlled mechanical ventilation all patients will be ventilated for 5 minutes with 100% oxygen. After 5 minutes an PaO2/FiO2 will be calculated and compared with a PaO2/FiO2 during ventilation with FiO2 - 30%.

The patients will be divided in two sections: Section A are the patients with less than 24 hours mechanical ventilation until weaning start. Section B are the patients with more than 24 hours until weaning start.

The patients in every section will be further divided in two groups. Group 1 will be weaned starting with a PEEP equal with P mean during BiPAP, Group 2 will be weaned starting with a PEEP equal with PEEP during BiPAP.

Further, the weaning will be conducted after an known algorithm. The differences in the oxygenation and decarboxylation will be measured after 30 and 120 Minutes for Group A and after 30, 120, 240, 360 Minutes for Group B.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: December 2018
• Est. primary completion date: November 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• All Patients that are mechanical ventilated on the intensive care unit.

Exclusion Criteria:

• Patients under 18 years of age

• Patients that where in an other study in the last 30 days

• Patients that are enrolled in other studies

• Pregnant woman

• Nursing mothers

• Existing severe Lung disease

• Existing COPD Gold IV

Related Conditions & MeSH terms

• Respiratory Failure
• Respiratory Insufficiency

Intervention

Other:
• PEEP adjusment during the Weaning process
The PEEP will be adjusted after an previously established algorithm and the differences in the arterial blood oxygen partial pressure will be compared.

Locations

Country	Name	City	State
Germany	Marienhospital Osnabrück	Osnabrück	Niedersachsen

Sponsors (1)

Lead Sponsor	Collaborator
Marienhospital Osnabrück

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in the Oxygen Partial Pressure and CO2 Partial Pressure in the arterial blood gas analysis		30, 60, 90, 120, 360 Minutes