Respiratory Failure Clinical Trial
Official title:
An Outbreak of Botulism in Thailand: Clinical Manifestations and Management of Severe Respiratory Failure
Verified date | August 2007 |
Source | Rajavithi Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Thailand: Ministry of Public Health |
Study type | Observational |
Background. Northern Thailand's biggest botulism outbreak to date occurred on 14 March 2006
and affected 209 people. Of these, 42 developed respiratory failure, and 25 of those who
developed respiratory failure were referred to 9 high facility hospitals for treatment of
severe respiratory failure and autonomic nervous system involvement. Among these patients,
we aimed to assess the relationship between the rate of ventilator dependence and the
occurrence of treatment by day 4 versus day 6 after exposure to bamboo shoots (the source of
the botulism outbreak), as well as the relationship between ventilator dependence and
negative inspiratory pressure.
Methods. The investigators reviewed the circumstances and timing of symptoms following
exposure. Mobile teams treated patients with botulinum antitoxin on day 4 or day 6 after
exposure in Nan Hospital (Nan, Thailand). Eighteen patients (in 7 high facility hospitals)
with severe respiratory failure received a low- and high-rate repetitive nerve stimulation
test, and negative inspiratory pressure was measured.
Status | Completed |
Enrollment | 18 |
Est. completion date | April 2006 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 1 Year and older |
Eligibility |
Inclusions: - Ate the bamboo shoots in Banluang district, on March,14 2006 - Clinical of respiratory failure and need ventilator assistant - Needed to referred to other hospital - The staffs of referred hospital willing to participate in the Thai Botulism study group Exclusion Criteria: - Patients who did not eat bamboo shoots in Banluang district on March14,2006. - No clinical of respiratory failure. - Not referred to other hospital. |
N/A
Country | Name | City | State |
---|---|---|---|
Thailand | Rajavithi Hospital | Bangkok |
Lead Sponsor | Collaborator |
---|---|
Rajavithi Hospital | Rajavithi Biomolecular Research Center |
Thailand,
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