Respiratory Failure Clinical Trial
Official title:
Etomidate Versus Midazolam for Pre-Hospital Intubation: A Prospective, Randomized Trial
The objective of this study was to compare the utility of etomidate and midazolam in helping patients to relax when there was a need for the placement of a ventilation tube by medics who were transporting patients to a hospital in an ambulance.
Study Objective: The objective of this study was to compare the utility of etomidate and
midazolam for sedative facilitated intubation (SFI), without paralytics, in pre-hospital
adult patients.
Methods: This prospective, double-blind, randomized trial was conducted with two ground
pre-hospital Advanced Life Support (ALS) units. All patients age 18 or over transported by
the two participating systems requiring pre-hospital SFI were eligible for participation.
The ambulances were stocked with blinded numbered syringes, each containing either 7mg of
midazolam or 20mg of etomidate. Contact with the Medic Command physician was not required
and no paralytics were used. If sedation was not achieved with the study drug, medics could
request additional sedation from a Medical command physician; only midazolam or diazepam
were available outside of the study.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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