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Respiratory Depression clinical trials

View clinical trials related to Respiratory Depression.

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NCT ID: NCT03050983 Completed - Clinical trials for Respiratory Insufficiency

Determination of the Clinical Impact of Continuous Surveillance Monitoring (SM) and Utility of IPI.

IPI
Start date: February 15, 2017
Phase:
Study type: Observational

Single site prospective observational nested study of bedside CS20p monitor on the GCF impeded into a retrospective review of the frequency of escalation of care with intermittent vitals signs compared to continuous respiratory monitoring.

NCT ID: NCT02987985 Completed - Anesthesia Clinical Trials

Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy

Start date: October 15, 2017
Phase: Phase 3
Study type: Interventional

The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the post-anesthesia care unit and ward in children with sleep-disordered breathing undergoing tonsillectomy when compared with traditional opioid-containing techniques. It is expected that this OFA regimen will have a measurable reduction on postoperative respiratory depression in children with sleep-disordered breathing.

NCT ID: NCT02907255 Completed - Clinical trials for Respiratory Depression

Vital Sign Monitoring With Continuous Pulse Oximetry and Wireless Clinician Notification After Surgery

VIGILANCE
Start date: October 2010
Phase: N/A
Study type: Interventional

Patients are at risk of respiratory depression after having surgery. The medications that patients are treated with to control their pain can impair their breathing and this can progress to respiratory and cardiac arrest and even death. Vital signs assessment on surgical wards is usually done every 4 hours and this may be insufficient to identify and manage many cases of respiratory depression. The aim of this study is to determine the impact on safety and nursing workflow of a respiratory monitoring on two surgical wards by measuring safety outcomes. Respiratory depression is a serious complication of pain treatment that can lead to patient complications and death. The level of monitoring available in hospitals by nursing staff is insufficient to manage this problem. If this new monitoring technology works as designed then patient safety can be improved while maintaining effective pain therapy.

NCT ID: NCT02903173 Completed - Pregnancy Clinical Trials

An Observational Study of Post-cesarean Delivery Respiratory Patterns Using a Non-invasive Minute Ventilation Monitor (Exspiron ™ System)

Start date: February 2015
Phase:
Study type: Observational

The purpose of this study is to evaluate the breathing patterns of women who undergo cesarean delivery with spinal or epidural morphine for post-operative pain control in the first day after surgery. Some women who undergo cesarean delivery may be at risk for respiratory complications related to opiate administration for post-operative pain. The primary aim of this study is to evaluate post-operative minute ventilation in women who undergo cesarean delivery using a novel method of non-invasive minute ventilation monitoring, and to see if there are predictive risk factors that may predispose women to post-operative hypoventilation.

NCT ID: NCT02885948 Completed - Clinical trials for Respiratory Depression

The Use of Low Dose Prophylactic Naloxone Infusion to Prevent Respiratory Depression With Intrathecal Morphine.

NAPRESSIM
Start date: April 2016
Phase: Phase 4
Study type: Interventional

This is an investigator led, randomised, double blind, placebo controlled, double arm comparator study.

NCT ID: NCT02819661 Recruiting - Clinical trials for Respiratory Depression

Respiratory Depression in Women With BMI≥30 Underwent Spinal Anesthesia With Intrathecal Morphine in Elective C-section

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The study will examine whether there is a difference in the frequencies of respiratory depression among obese women receiving spinal anesthesia combined with opioids compared to women with normal BMI. If such a risk exists further investigation will be required to establish the proper criteria for the administration of morphine with spinal anesthesia to obese women.

NCT ID: NCT02811302 Completed - Clinical trials for Respiratory Depression

PRediction of Opioid-induced Respiratory Depression In Patients Monitored by capnoGraphY

PRODIGY
Start date: April 7, 2017
Phase: N/A
Study type: Interventional

PRODIGY is a prospective, multi-center, post-market, international cohort study. The primary objective of this study is to derive a score to identify subjects at risk to have respiratory depression (RD) episodes in patients undergoing opioid therapy in the hospital ward and monitored by capnography. The score will be derived by using subjects within the derivation cohort and internally validated using subjects within the validation cohort. The primary endpoint used to derive the score will be the occurrence of RD episodes derived by Capnostream 20p device memory data combined with clinical data and validated by an independent Clinical Endpoint Committee (CEC) during the study course.

NCT ID: NCT02804022 Active, not recruiting - Clinical trials for Respiratory Depression

Vital-signs-integrated Patient-assisted Intravenous Opioid Analgesia

VPIAmorphine
Start date: December 29, 2016
Phase: Phase 2
Study type: Interventional

This is a closed-loop system which is embodied in a novel and intelligent algorithm that takes into account patients' vital signs. The system allows better and responsive titration of personalized pain relief together with non-invasive physiological monitoring that measures oxygenation, breathing and heart rate continuously.

NCT ID: NCT02760927 Terminated - Respiratory Failure Clinical Trials

Assessment of a Oral Endotracheal Tube Fastener on Patients Intubated With Oral Endotracheal Tubes

Start date: March 2016
Phase: N/A
Study type: Interventional

Assessment of AnchorFast Guard Oral Endotracheal Tube Fastener on Patients Intubated with Oral Endotracheal Tubes with Subglottic Suction

NCT ID: NCT02707003 Completed - Clinical trials for Respiratory Depression

Clinical Utility of Capnography in the PACU( Post-anaesthesia Care Unit)

Start date: February 2016
Phase:
Study type: Observational

Multi-center observational trial with study device blinded in order to assess in parallel standard monitoring and intervention practices related to management of respiratory compromise in the post-anaesthesia care unit (PACU)