Resistant Hypertension Clinical Trial
1. (RENEWAL-EXERCISE trial) The investigators hypothesize that the increased sympathetic
nervous system activation that is associated with resistant hypertension is a major
contributor in the pathogenesis of exercise diastolic dysfunction and that modulation of
the sympathetic nervous system activity with radiofrequency ablation of the renal artery
sympathetic nerve fibers delivered via a treatment catheter, will have a significant
effect on the diastolic function that is beyond BP-lowering effect.
2. (RENEWAL-REGRESSION trial) The major cause of mortality and morbidity in hypertension is
atherosclerotic cardiovascular disease. the significant decrease in the sympathetic
nervous system activation after renal sympathetic denervation will contribute to
regression over and beyond it's effect of blood pressure reduction.
3. (RENEWAL-PREDICT trial) No data exists regarding the tests or methods predicting the
successful renal denervation causing the effective reduction of BP. For these, the
investigators sought to perform the new tests such as adenosine infusion test during
procedure and skin sympathetic activity measurement before and immediate post-procedure
(detailed explanation provided in section of Methods) and then evaluate the association
between these tests and reduction of BP following procedures.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
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Phase 3 | |
| Not yet recruiting |
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Phase 2 | |
| Withdrawn |
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Rapid Renal Sympathetic Denervation for Resistant Hypertension II
|
Phase 2/Phase 3 | |
| Recruiting |
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|
||
| Recruiting |
NCT04213963 -
Prospective Study on Primary Aldosteronism in Resistant Hypertension
|
||
| Recruiting |
NCT05563077 -
Aerobic Exercise and Resistant Hypertension
|
N/A | |
| Recruiting |
NCT03758196 -
Renal Sympathetic Denervation From the Adventitia on Resistant Hypertension（RSDARH）
|
N/A | |
| Active, not recruiting |
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CALM- 2 - Controlling and Lowering Blood Pressure With the MobiusHD™
|
N/A | |
| Completed |
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A Study of CIN-107 in Adults With Treatment-Resistant Hypertension (rHTN)
|
Phase 2 | |
| Not yet recruiting |
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Remote Ischemic Conditioning for the Treatment of Resistant Hypertension
|
N/A | |
| Not yet recruiting |
NCT05552300 -
Superselective Adrenal Arterial Embolization for Resistant Hypertension
|
N/A | |
| Completed |
NCT04345198 -
Adrenal Artery Ablation for Primary Aldosteronism With Resistant Hypertension
|
N/A | |
| Active, not recruiting |
NCT05562934 -
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|
Phase 2 | |
| Recruiting |
NCT06034743 -
A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension
|
Phase 3 | |
| Withdrawn |
NCT02926495 -
Subcutaneous Median Nerve Neuromodulation For Drug-Treatment Resistant Hypertension.
|
N/A | |
| Active, not recruiting |
NCT02670681 -
Effects of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects
|
N/A | |
| Completed |
NCT02572024 -
The Effect of BATon BP and Sympathetic Function in Resistant Hypertension (The Nordic BAT Study)
|
N/A | |
| Terminated |
NCT02295683 -
Renal Sympathetic Denervation by Iberis System in Patients With Uncontrolled Hypertension - Iberis-HTN Registry
|
||
| Completed |
NCT02001350 -
Carotid Ultrasound Study
|
N/A | |
| Recruiting |
NCT04331691 -
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|
Phase 4 |