Metabolic Workup in Patients Suffering From Kidney Stone Disease &

Status Not yet recruiting

Clinical Trial Summary

Patients suffering from acute renal colic are evaluated by non contrast computerized tomography with excellent identification rates of urinary stones. The scan also covers the bones of the ribs, spine and pelvis, allowing measurements of the bone density and identifying early osteopenic changes. Bone demineralization is associated with metabolic changes such as hypercalcemia or hypercalcuria. In this study the investigators will look for correlation between kidney stones, osteopenic bone changes and metabolic abnormalities.

Clinical Trial Description

Kidney stones are a common medical condition found in more then 5% of the adult population. The stones might cause severe pain (due to acute obstruction of a renal unit) , deterioration of renal function and urinary tract infection. One of the causes of kidney stones is metabolic changes such as hypercalcemia or hyperoxaluria. Basic evaluation of kidney stones patients include measurements of calcium, phosphor and uric acid in the serum and is often negative. Thorough metabolic workup including 24 hours urine collection is not cost effective and is reserved for patients with frequent recurrence of stone disease.

Metabolic abnormalities are often associated with bone demineralization, of which the patients are typically unaware. such changes can be detected by the CT scan. On the same scan, performed for identifying the stone, the radiologist can measure bone density, using the Hounsfield units, in the L2 vertebral body of and the acetabular area of the pelvis.

In the study, in all patients undergoing CT scan due to renal colic, the bone density will be measured. Patients with abnormal bone density will undergo a complete metabolic workup including 24 hours collection of urine and measurements of urinary clearance of calcium, phosphorous, uric acid, oxalate and citrate . The investigators will look for correlation between osteopenic changes and metabolic abnormalities. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04080973
Study type	Interventional
Source	Ziv Hospital
Contact	Ran Katz, MD
Phone	97246828775
Email	ran.k@ziv.health.gov.il
Status	Not yet recruiting
Phase	N/A
Start date	October 2019
Completion date	October 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04754711` - Interest of Nutritional Care of Children With Sickle Cell Disease on Bone Mineral Density and Body Composition	N/A
Active, not recruiting	`NCT05066477` - A Clinical Trial Investigating the Effect of Salmon Bone Meal on Bone Mass Among Osteopenic Women	N/A
Terminated	`NCT01902186` - Bone Mineral Density Changes in HIV-positive Females With Osteopenia Switching to Raltegravir	Phase 4
Completed	`NCT01439139` - Bone UltraSonic Scanner (BUSS): Validation Study	N/A
Not yet recruiting	`NCT01397838` - Safety Study of an Oral Pro-boneTM, Administered to Post Menopausal Osteopenic Women	Phase 1
Completed	`NCT01222026` - Systematic Treatment After Successful Surgical Treatment for Primary Hyperparathyroidism With Strontium Ranelate	Phase 4
Completed	`NCT00789425` - Investigating the Effect of Standardized Olive Extract on Bone Turnover Markers in Postmenopausal Women	Phase 2
Completed	`NCT01152580` - Melatonin Osteoporosis Prevention Study	Phase 1
Completed	`NCT00463268` - Osteoporosis Prevention With Low Dose Alendronate	Phase 3
Completed	`NCT00655681` - Prevention of Post Operative Bone Loss in Children	N/A
Completed	`NCT00798473` - Zoledronate for Osteopenia in Pediatric Crohn's	Phase 3
Active, not recruiting	`NCT00076050` - Using Soy Estrogens to Prevent Bone Loss and Other Menopausal Symptoms	Phase 3
Completed	`NCT00226031` - Optimal Management of Women With Wrist Fractures	N/A
Enrolling by invitation	`NCT04752098` - A Study to Assess Metabolic Bone Disease of Prematurity Using an Acoustic Method	N/A
Completed	`NCT04720833` - Effect of Dried Plum on Bone and Markers of Bone Status in Men	N/A
Recruiting	`NCT05541432` - Finding the Optimal Resistance Training Intensity For Your Bones	N/A
Active, not recruiting	`NCT05405894` - Efficacy of Zoledronic Acid to Prevent Bone Loss Following Denosumab Discontinuation
Completed	`NCT05457036` - Evaluation of the Effect of Spry Belt Treatment on Bone Turnover Marker Profile	N/A
Completed	`NCT04040010` - The Effects of Bovine Colostrum in Bone Metabolism in Humans	N/A
Completed	`NCT02731820` - Efficacy of Potassium Citrate in the Treatment of Postmenopausal Osteopenia	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Metabolic Workup in Patients Suffering From Kidney Stone Disease and Osteopenia

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms