MOdularity for SEnsory Motor Control — MOSE  

Rehabilitation Clinical Trial

Official title: MOdularity for SEnsory Motor Control: Implications of Muscle Synergies in Motor Recovery After Stroke

Status Active, not recruiting

Clinical Trial Summary

For this project the investigators ask, how the activation and organization of muscle synergies may be disrupted by brain lesions, and whether it is possible to modify synergy activations by means of specific therapies. Will be investigated whether there is a relationship between post-stroke cortical plasticity and changes in synergy activations due to a therapy.

Clinical Trial Description

It has been widely recognized that neurorehabilitation can facilitate recovery of motor function after stroke. There has been increasing evidence suggesting that the execution of voluntary movement relies critically on the functional integration of the motor areas and the spinal circuitries. More precisely, it was suggested that the central nervous system may generate neural motor commands through a linear combination of spinal modules, each of which activates a group of muscles as a single unit (muscle synergy). The investigators hypothesize that descending motor cortical signals generate movements by combining and activating muscle synergies. With this background, the goal is to further improve the efficacy of rehabilitation utilizing knowledge on modular motor control. The investigators also seek to provide a better understanding of the links between brain activations and movements.

The project MO-SE has three aims, one primary and two secondary. The main primary aim is to test whether the use of virtual reality rehabilitation based therapies are superior in terms of clinical efficacy to conventional therapies (randomized clinica trial, RCT). The other two secondary aims of the project will be accomplished with further instrumental analysis in sub-samples of the group of patients enrolled for the RCT. ;

Related Conditions & MeSH terms

• Arm Injuries
• Ischemic Stroke
• Rehabilitation
• Stroke, Ischemic
• Upper Limb Injury

• NCT number: NCT03530358
• Study type: Interventional
• Source: IRCCS San Camillo, Venezia, Italy
• Status: Active, not recruiting
• Phase: N/A
• Start date: December 1, 2014
• Completion date: December 1, 2022