Microcirculation Clinical Trial
Official title:
Role of NO in the Control of Choroidal Blood Flow During a Decrease in Ocular Perfusion Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in
perfusion pressure. For a long time it had been assumed that the choroid is a strictly
passive vascular bed, which shows no autoregulation. However, recently several groups have
identified some autoregulatory capacity of the human choroid. In the brain and the retina
the mechanism behind autoregulation is most likely linked to changes in transmural pressure.
In this model arterioles change their vascular tone depending on the pressure inside the
vessel and outside the vessel. In the choroid, several observations argue against a direct
involvement of arterioles. However, the mechanism behind choroidal autoregulation remains
unclear.
In the present study autoregulation of the choroid will be investigated during a decrease in
ocular perfusion pressure, which will be achieved by an increase in intraocular pressure.
Pressure/flow relationships will be investigated in the absence or presence of a NO synthase
inhibitor. As a control substance the alpha-receptor agonist phenylephrine will be used.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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