Cardiomyopathies Clinical Trial
Official title:
Index of Microcirculatory Resistance (IMR) Assessment in Patients With New Diagnosis of Left Ventricular Dilatation Without Significant Coronary Artery Lesions: IMPAIRED Pilot Trial
To establish if, in patients with new diagnosis of left ventricular dilatation without documentation at the coronary artery angiography of significant coronary artery lesions, there is a damage of the coronary microcirculation at the IMR (index of microcirculatory resistance) assessment
The Authors will enroll at the moment of coronary artery angiography patients without history
of ischemic heart disease and new diagnosis (at transthoracic echocardiography) of left
ventricular dilation.
All patients will undergo coronary artery angiography. To be enrolled, it is necessary to
have the absence of significant coronary artery stenosis (angiographic evaluation of the
lesion >40%) in all the vessels (main and side branch).
The Authors will proceed to perform the evaluation of the index of microvascular resistance
(IMR). The target vessel will be the left anterior descending artery.
An intracoronary pressure/temperature sensor-tipped guidewire will be used. Thermodilution
curves will be obtained during maximal hyperemia. The IMR will be calculated from the ratio
of the mean distal coronary pressure at maximal hyperemia to the inverse of mean hyperemic
transit time.
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