ATP Level and Cough Sensitivity to ATP in Subjects With Refractory Chronic Cough

Refractory Chronic Cough Clinical Trial

Official title:

ATP Level in Induced Sputum and Cough Sensitivity to ATP in Subjects With Refractory Chronic Cough

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05265871
• Other study ID #: RCC-ATP
• Status: Not yet recruiting
• Start date: April 15, 2022
• Est. completion date: May 16, 2023

Study information

• Verified date: February 2022
• Source: The First Affiliated Hospital of Guangzhou Medical University
• Contact: Kefang Lai, MD
• Phone: +86 18928868231
• Email: klai[@]vip.163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is a prospective case - control study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory chronic cough. 60 refractory chronic cough and 30 matched healthy controls were recruited. Medical history records, cough severity assessment, induced sputum for ATP measurement, ATP evoked cough and capsaicin evoked cough were completed. The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 90
• Est. completion date: May 16, 2023
• Est. primary completion date: April 16, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Chronic cough as sole symptom lasting =6 months;

2. No potential causes were identified after full investigations or cough persisted after treatment trials directed to potential causes;

3. Cough Visual Analogue Score =30mm.

Exclusion Criteria:

1. Current or recent smokers (<6 months abstinence) , those with >20 pack-year smoking history;

2. With a forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio <60%;

3. With a history of upper respiratory tract infection or significant change in pulmonary status within 4 weeks.

Related Conditions & MeSH terms

• Cough
• Refractory Chronic Cough

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Kefang Lai

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	ATP level in sputum	ATP level in induced sputum in subjects with refractory chronic cough and healthy control	2022/04/01-2023/04/02
Secondary	ATP cough sensitivity	cough sensitivity for ATP in subjects with refractory chronic cough and healthy control	2022/04/01-2023/04/02