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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT05265871
Other study ID # RCC-ATP
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date April 15, 2022
Est. completion date May 16, 2023

Study information

Verified date February 2022
Source The First Affiliated Hospital of Guangzhou Medical University
Contact Kefang Lai, MD
Phone +86 18928868231
Email klai@vip.163.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This is a prospective case - control study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory chronic cough. 60 refractory chronic cough and 30 matched healthy controls were recruited. Medical history records, cough severity assessment, induced sputum for ATP measurement, ATP evoked cough and capsaicin evoked cough were completed. The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 90
Est. completion date May 16, 2023
Est. primary completion date April 16, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria: 1. Chronic cough as sole symptom lasting =6 months; 2. No potential causes were identified after full investigations or cough persisted after treatment trials directed to potential causes; 3. Cough Visual Analogue Score =30mm. Exclusion Criteria: 1. Current or recent smokers (<6 months abstinence) , those with >20 pack-year smoking history; 2. With a forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio <60%; 3. With a history of upper respiratory tract infection or significant change in pulmonary status within 4 weeks.

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Kefang Lai

Outcome

Type Measure Description Time frame Safety issue
Primary ATP level in sputum ATP level in induced sputum in subjects with refractory chronic cough and healthy control 2022/04/01-2023/04/02
Secondary ATP cough sensitivity cough sensitivity for ATP in subjects with refractory chronic cough and healthy control 2022/04/01-2023/04/02
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