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RP3 in Combination With 1L or 2L Therapy in Patients With Locally Advanced Unresectable or Metastatic HCC

Recurrent Hepatocellular Carcinoma Clinical Trial

Official title:
A Phase 2, Open-label, Multicenter Study Investigating RP3 Oncolytic Immunotherapy in Combination With First- or Second-line Therapy in Patients With Locally Advanced Unresectable or Metastatic Hepatocellular Carcinoma

Clinical Trial Summary

This is a Phase 2, open-label, 2-cohort clinical study evaluating RP3 in combination with atezolizumab plus bevacizumab as First- or Second-line Systemic Therapy in patients with locoregionally advanced and/or metastatic Hepatocellular Carcinoma not amenable to surgical resection or standard locoregionally directed therapies.

Clinical Trial Description

RP3 is a genetically modified herpes simplex type 1 virus (HSV-1) that expresses exogenous genes (anti-CTLA-4 antibody, CD40 ligand and h4-1BBL) designed to directly kill tumor cells and generate a systemic anti-tumor immune response ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05733598
Study type Interventional
Source Replimune Inc.
Contact Clinical Trials at Replimune
Phone 1-781-222-9570
Email Clinicaltrials@replimune.com
Status Not yet recruiting
Phase Phase 2
Start date April 1, 2024
Completion date July 1, 2027
View Details
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