Two-week Course Versus Conventionally Fractionated Chemoradiotherapy in

Status Recruiting

Clinical Trial Summary

The investigators compare two-week course of chemoradiation (33 Gy in 10 fractions with oral capecitabine) and conventional chemoradiation (50.4 Gy in 28 fractions with 5-FU and leucovorin) in this randomized trial.

Clinical Trial Description

1.1 experimental arm Two-week course concurrent chemoradiotherapy

- Radiotherapy, 33 Gy/10 fractions for 2 weeks

↓↓↓↓↓ ↓↓↓↓↓ Radical surgery 6 weeks after completion of chemoradiotherapy D1----------------------D12

- Capecitabine 825 mg/m2, twice daily

1.2 control arm

Standard concurrent chemoradiotherapy (CRT)

- Radiotherapy, 50.4 Gy/28 fractions for 6 weeks

↓↓↓↓↓ ↓↓↓↓↓ ↓↓↓↓↓ ↓↓↓↓↓ ↓↓↓↓↓ ↓↓↓ Radical surgery D1--------------------------------------------------------------------------D38

- Bolus 5-FU, 400 mg/ m2 and leucovorin, 20 mg/ m2 during week 1 and 5

- Capecitabine, 825 mg/ m2, bid ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02484040
Study type	Interventional
Source	Seoul St. Mary's Hospital
Contact	Jong Hoon Lee, MD
Phone	+82-031-249-8440
Email	koppul@catholic.ac.kr
Status	Recruiting
Phase	Phase 3
Start date	December 2015
Completion date	July 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03545659` - Childhood Acute Lymphoblastic Leukaemia: Follow-Up
Completed	`NCT04838613` - Study of Diagnostic Performance of [18F]CTT1057 in BCR	Phase 3
Recruiting	`NCT05233020` - Robotic Versus Hybrid Assisted Ventral Hernia Repair	N/A
Recruiting	`NCT04266600` - Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease	N/A
Recruiting	`NCT04539665` - Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease.	N/A
Terminated	`NCT03257722` - Pembrolizumab + Idelalisib for Lung Cancer Study	Phase 1/Phase 2
Completed	`NCT01141335` - Polypropylene Mesh Versus Polytetrafluoroethylene (PTFE) Mesh in Inguinal Hernia Repair	Phase 4
Completed	`NCT00029185` - Study of Dehydrex in Patients With Corneal Erosion	N/A
Completed	`NCT01351974` - Sentinel Node Biopsy in Breast Cancer Patients	N/A
Not yet recruiting	`NCT06038422` - GTP Regimen in the Treatment of Refractory/Recurrent HLH	Phase 3
Withdrawn	`NCT03162120` - Comparison of Effectiveness of Ranolazine Plus Metoprolol Combination vs. FlecainidE pluS Metoprolol Combination in ATrial Fibrillation Recurrences FOllowing PhaRmacological or Electrical CardioverSion of AtRial Fibrillation	Phase 2/Phase 3
Recruiting	`NCT04159051` - Charité HT-Prostate	N/A
Recruiting	`NCT02566928` - Patient-Centered Comparative Effectiveness Research (CER) Study of Home-based Interventions to Prevent CA-MRSA Infection Recurrence	Phase 4
Completed	`NCT01989845` - Rivaroxaban for the Prevention of Venous Thromboembolism in Asian Patients With Cancer	Phase 4
Recruiting	`NCT01229475` - Stepwise Approach Versus Linear Ablation in Patients With Recurrence of Persistent Atrial Fibrillation	N/A
Completed	`NCT00944554` - Relapse Prevention With Varenicline	Phase 4
Terminated	`NCT02247258` - Azathioprine in the Prevention of Ileal Crohn's Disease Postoperative Recurrence.	Phase 2
Completed	`NCT03654209` - Post-resection Treatment of Large Colon Polyps	N/A
Recruiting	`NCT05557474` - Development and Clinical Validation of Early-stage Lung Cancer Prognostic Kit
Active, not recruiting	`NCT03865537` - Cold Snare Endoscopic Mucosal Resection Trial	N/A

Two-week Course Versus Conventionally Fractionated Chemoradiotherapy in Rectal Cancer

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms