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NCT04598984 Clinical Trial

The Role of Serum Adipokines in Predicting Response to Neoadjuvant Therapy in Patients With Rectal Cancer

Rectal Cancer Stage III Clinical Trial

Official title:
The Role of Serum Adipokines in Predicting Response to Neoadjuvant Therapy in Patients With Rectal Cancer

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04598984
Other study ID # 2506
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date September 1, 2020
Est. completion date December 31, 2022

Study information
Verified date August 2022
Source Istanbul Training and Research Hospital
Contact Cihad Tatar, MD
Phone +905336599889
Email tatarcihad@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

It has been shown that adipokines (resistin, leptin, adiponectin) secreted from adipose tissue and proinflammatory cytokines such as IL-6, TNF-a are associated with the risk of developing colorectal cancer. However, the role of these factors in predicting clinical response to neoadjuvant therapy in rectal cancers is unknown. In this study, the role of serum adipokine levels before neoadjuvant therapy in predicting clinical response in patients with rectal cancer is investigated. For this purpose, blood will be drawn from patients with rectal cancer who will receive neoadjuvant therapy, serum adipokines will be studied and clinical response to neoadjuvant therapy will be compared.

Recruitment information / eligibility
Status Recruiting
Enrollment 60
Est. completion date December 31, 2022
Est. primary completion date December 30, 2022
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - All patients with locally advanced rectal cancer Exclusion Criteria: - below 18 years old - patients who did not received neoadjuvant therapyAll

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• serum adipokines
Level of serum adipokines will be measured with flow cytometry

Locations
Country Name City State
Turkey Istanbul Training and Research Hospital Istanbul

Sponsors (1)
Lead Sponsor Collaborator
Istanbul Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary The Role of Serum Adipokines in Predicting Response to Neoadjuvant Therapy in Patients with Rectal Cancer The Adiponectin, Adipsin, Leptin, Resistin levels will be measured with flow cytometric analysis. 1 year
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