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Optimal Surgery and MRI Based Radiochemotherapy in Rectal Carcinoma — OCUM  

Rectal Cancer Stage III Clinical Trial

Official title:
Optimal Surgery With Total Mesorectal Excision and MRI Based Multimodal Therapy of Rectal Carcinoma

Clinical Trial Summary

The objective of the study is to provide proof that a MRI based preoperative radiochemotherapy in patients with locally advanced rectal carcinoma allows limiting RCT to high risk patients without increase of locoregional recurrence rate and decrease of overall survival provided there is a high quality of mesorectal excision.

Clinical Trial Description

The criteria for application of RCT is the distance of the tumor from mesorectal fascia in preoperative MRI of the pelvis. In case of a T 4 tumor or a tumor with a distance of 1mm of less form mesorectal fascia long-course radiochemotherapy is applied followed by surgery, in all other cases primary surgery is done. ;

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01325649
Study type Observational
Source Johannes Gutenberg University Mainz
Contact
Status Completed
Phase N/A
Start date February 2009
Completion date September 2016
View Details
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