Radiomics of Mp-MRI Assessing NAC Outcome in Breast Cancer

Status Recruiting

Clinical Trial Summary

This is a single-arm, multicentre study that aims to assess whether Radiomics combining multiparametric MRI and clinical data could be a good predictor of the responses to neoadjuvant chemotherapy in Breast Cancer.

Clinical Trial Description

Patients undergo multiparametric MRI (including T2WI, DWI and DCE-MRI) at baseline, after 2 courses of neoadjuvant chemotherapy, and prior to the surgery at least 8 weeks after the treatment procedure. Patients undergo biopsy test in one week after the baseline MRI scan to detect the biomarkers including ER, PR, Her-2 and Ki-67, which can be used to select the treatment plan referring to the NCCN clinical guidelines. After the surgery, responses to neoadjuvant chemotherapy are determined according to the histopathologically examination of the surgically resected specimens.

After completion of treatment procedure, patients are followed up for 5 years. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03592004
Study type	Observational
Source	Chinese Academy of Sciences
Contact	Zhenyu Liu, Doctor
Phone	8613466358609
Email	zhenyu.liu@ia.ac.cn
Status	Recruiting
Phase
Start date	July 18, 2018
Completion date	June 1, 2022

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