Radiation-Induced Intestinal Injury Clinical Trial
Official title:
Efficacy and Safety of Local Glucocorticoids for the Treatment of Radiation-Induced Intestinal Injury: A Randomized Controlled Trial
Due to the increasing number and prolonged survival of malignant tumor patients treated with radiotherapy, the complication, such as radiation-induced intestinal injury, has become increasingly significant. Glucocorticoids may play a therapeutic role by regulating the inflammatory response in patients with radiation-induced intestinal injury. However, the conclusions of related studies were controversial.
A total of 60 patients with radiation-induced intestinal injury will be enrolled. They will be randomly assigned at a 1:1 ratio into glucocorticoid group and standard treatment group. The primary endpoint is the improvement of radiation-induced intestinal injury. The secondary study endpoints include the recurrence and aggravation of radiation-induced intestinal injury, and adverse events. ;