The Value of Central Venous-arterial Carbon Dioxide Difference

Status Completed

Clinical Trial Summary

By observing the changes of Central venous-arterial partial pressure difference of carbon dioxide [P (v-a) CO2] in liquid resuscitation during early escharectomy in patients with large-scale burns, We investigate the effect of P (v-a) CO2 on postoperative tissue perfusion and oxygenation in order to seek a more effective intergrated target plan of liquid resuscitation for burn patients.

Clinical Trial Description

Objective: By observing the changes of Central venous-arterial partial pressure difference of carbon dioxide [P (v-a) CO2] in liquid resuscitation during early escharectomy in patients with large-scale burns, We investigate the effect of P (v-a) CO2 on postoperative tissue perfusion and oxygenation in order to seek a more effective intergrated target plan of liquid resuscitation for burn patients. Methods: a prospective observational study was conducted on 145 patients with extensive burns admitted to surgical intensive care unit（SICU）of Guangzhou Red Cross hospital from January 2016 to December 2019. All patients received hemodynamic monitoring and goal-directed fluid therapy, patients with central venous oxygen saturation (ScvO2)< 70% were excluded. Patients were divided into the following groups according to the changing trend of Pcv-aCO2 between T base (before induction) and T 0h (after surgery) : group 1 (H-H) : Pcv-aCO2≥6mmHg between T base and T 0h. Group 2 (L-H) : Pcv-aco2< 6mmHg at T base and≥6mmHg at T 0h; Group 3 (H-L) : Pcv-aCO2≥6mmHg at T base and < 6mmHg at T 0h. Group 4( L-L) : Pcv-aCO2 < 6mmHg between T base and T0h.Postoperative basic physiological indicators such as heart rate（HR）, blood pressure, central venous pressure (CVP), cardiac output index (CI), Pcv-aCO2 and lactic acid were recorded at 0 and 18 hours after surgery. Oxygen dynamic indicators such as oxygen delivery index (DO2I), oxygen consumption index (VO2I), oxygen uptake rate (O2ER) and so on were calculated. Pearson correlation analysis was used to evaluate the correlation between Pcv-aCO2 and CI. The change of tissue perfusion and oxygenation with different levels of Pcv-aCO2 after fluid resuscitation were analyzed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04761237
Study type	Interventional
Source	Guangzhou Red Cross Hospital
Contact
Status	Completed
Phase	N/A
Start date	January 1, 2017
Completion date	December 30, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04080700` - Korean Prospective Registry for Evaluating the Safety and Efficacy of Distal Radial Approach (KODRA)
Recruiting	`NCT04257747` - Qualitative and Quantitative Evaluation of Vascular Flows of Radial, Ulnar and Interdigital Arterial Trees Under Normal and Pathological Conditions by 3 Tesla MRI	N/A
Completed	`NCT03626129` - Oximetry Guided Versus Traditional Rapid Deflation Technique for Achieving Hemostasis After Radial Procedures	N/A
Completed	`NCT05982366` - Feasibility and Safety of the Routine Distal Transradial Approach	N/A
Completed	`NCT05771935` - Ultrasound Guided Ulnar Versus Radial Artery in Pediatrics Undergoing Major Non Cardiac Surgery	N/A
Recruiting	`NCT04802252` - A Diagnostic Study of Abnormal Acoustic Waves in Modern Pulse in Benign Prostatic Hyperplasia
Completed	`NCT04303923` - Reference Diameter and Characteristics of Distal Radial Artery by Ultrasonographic Assessement in Korean Patients
Completed	`NCT04001764` - Comparison of the Efficacy of Radial Artery Catheterization in Three Different Regions in Intensive Care Patients	N/A
Recruiting	`NCT04717661` - A Diagnostic Test Study of Characteristic Sound Waves in Radial Artery of Early Pregnant Women
Completed	`NCT01789801` - A Randomized Study Evaluating the Role of Ultra-sound Guidance When Drawing Radial Arterial Blood Samples	N/A
Recruiting	`NCT03405428` - Ultrasonography For Radial Artery Diameter Measurement And Its Correlation With Allen Test	N/A
Completed	`NCT03620383` - Radial Artery Vasodilation Heat Study	Phase 1/Phase 2
Completed	`NCT01189188` - Ultrasound Guidance for Radial Arterial Blood Sampling	N/A
Recruiting	`NCT04857736` - A Diagnostic Test Study of Characteristic Sound Waves in Radial Artery During Menstruation in Healthy Female College Students
Recruiting	`NCT04861883` - A Diagnostic Test Study of Characteristic Sound Waves in the Middle and Third Trimester of Pregnancy Women
Recruiting	`NCT04859712` - A Diagnostic Test of Abnormal Sound Waves in Modern Pulsology of Lumbar Disc Herniation
Not yet recruiting	`NCT05511675` - The Effect of Cold Application on the Hemostasis, Extremity Pain And Terumo Band Usage After Transradial Angiography	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.