Quality of Life Clinical Trial
Official title:
Long-acting Versus Short-acting Granulocyte Colony Stimulating Factor for the Prevention of Febrile Neutropenia in Epithelial Ovarian Cancer Patients: A Multicenter Phase 3 Randomized Controlled Study
This study aims to analyze the effects of long-acting versus short-acting granulocyte colony
stimulating factor (G-CSF) on the prevention febrile neutropenia (FN) in epithelial ovarian
cancer patients.
Patients receive platinum-based chemotherapy of 3 to 4 weeks. Patients are randomized into
study group and control group. In study group, patients accept long-acting G-CSF 48 hours
from the chemotherapy. While the control group accept regular or prophylactic treatment of
short-acting G-CSF according to National Comprehensive Cancer Network guidelines.
The primary end is the incidence of FN in every course of chemotherapy.
The secondary ends include: the incidences of myelosuppression, doses of G-CSF and its
expenses, visits to outpatient and emergency clinics, adverse events related to G-CSF,
quality of life, and survival outcomes (progression-free survival and overall survival).
n/a
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