Quality of Life Clinical Trial
Official title:
Impact of Adjuvant Chemotherapy on the Quality of Life of Patients Treated for Stage II / III Endometrial Cancer
Through this study, The investigator believe to evaluate the impact in terms of overall quality of life of adjuvant chemotherapy in patients with locally advanced endometrial cancer at a distance from their care
Endometrial cancer is the fourth most common cancer in women in developed countries. The
diagnosis is often made at a localized stage (67% of cases), making it a relatively good
cancer prognosis with a 5-year all-stage survival of 81.7%.
Its management at the localized stage is based on surgery and radiotherapy. Adjuvant
chemotherapy may be offered in addition to radiotherapy, but its place is still debated. It
is classically delivered sequentially before or after radiotherapy, concomitant
radiochemotherapy not being a standard. It is generally recommended in case of stage III, and
for the earlier stages, its use is based on various prognostic factors (histological type,
grade, emboli) and the feasibility of treatment (age, general condition, comorbidities). In
fact, patients treated for endometrial cancer are elderly (median age 63 years) and in the
majority of cases present comorbidities (diabetes, obesity and hypertension). Chemotherapy
can induce side effects that can persist and potentially alter the quality of life of these
often fragile patients. Although the impact of surgery and radiotherapy on the quality of
life has been well studied, there is insufficient literature data for adjuvant chemotherapy.
The investigator propose a case-control study that will evaluate the quality of life and late
sequelae of patients treated for locally advanced endometrial cancer with sequential adjuvant
chemotherapy before or after radiotherapy at a distance from their management. comparing
their results to a group of patients who had been treated with postoperative radiotherapy
alone.
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