Quality of Life Clinical Trial
Official title:
Treatment of Atraumatic Bone Marrow Edema With Denosumab and Teriparatide vs Placebo
The etiology of bone marrow edema (BME) is still uncertain. Several studies report
therapeutic success with antiresorptive drugs.
This study investigates antiresorptive and osteoanabolic drugs versus placebo in BME
Patients are assigned to receive either denosumab 60mg sc (once) or placebo or daily
teriparatide sc for three months or placebo.
MRI examinations at baseline and after three months will be performed. Serum bone turnover
markers will be evaluated as well as QoL questionnaires.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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