Laser Activated Irrigation Versus Passive Ultrasonic Irrigation

Status Not yet recruiting

Clinical Trial Summary

assessment of bacterial reduction and post-operative pain following Laser activated irrigation using sodium hypochlorite and a 980 nm diode laser device as an adjunct to conventional root canal treatment, and comparing it with passive ultrasonic irrigation using sodium hypochlorite and an ultrasonic device in patients with single rooted asymptomatic necrotic teeth.

Clinical Trial Description

After thorough diagnosis and recording of the patient's perceived preoperative pain using the numeric rating scale (NRS), which should be zero. Patients with single rooted necrotic teeth will be randomly divided into two groups for endodontic treatment in a single visit:

Group LAI (in which laser activated irrigation will be done) and group PUI (in which passive ultrasonic irrigation will be done).

The teeth are anesthetized and isolation is done. the clamp, tooth crown and rubber dam are disinfected using 2.5% sodium hypochlorite and 30% hydrogen peroxide then sodium thiosulphate to neutralize their effects.

Removal of caries and defective restorations is done, followed by access cavity preparation using round burs and fine tapered stones. then the first microbiological sample is taken using paper points. Afterwards root canal preparation is done using Protaper Next files and irrigation is done using 2.5% sodium hypochlorite and a 30 -gauge side vented needle.

After chemomechanical preparation of the canal, the second microbiological sample is taken, afterwards the canals are filled with sodium hypochlorite and according to the group, the following is done:

In group LAI: the 200 micrometer fibre of the diode laser device enters the root canal and the device is activated at a setting of 980 nm and 1.5 Watts for 5 seconds, repeated 4 times with a 10 seconds gap in between.

In group PUI: the ultrasonic device is activated inside the canal using a passive non cutting tip and kept activated for 1 minute.

Then, irrigation with saline solution is done then the third microbiological sample is taken, afterwards obturation is done and temporization. the patient is referred to the restorative dentistry clinic to complete the restoration of his tooth.

The patient is instructed to record his pain at 6,12,24 and 48 hours postoperatively and the microbiological samples are analyzed ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04035083
Study type	Interventional
Source	Cairo University
Contact	Amr Ahmed, MSc
Phone	+201224382216
Email	dramrayman1@gmail.com
Status	Not yet recruiting
Phase	N/A
Start date	September 2019
Completion date	September 2021

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT05728346` - The Efficacy and Safety of Pulp Regeneration Induced by SHED Polymerization	N/A
Completed	`NCT04638972` - Accuracy of Apex Locators in Primary Teeth
Completed	`NCT05181813` - Treatment of Infected Pulp in Primary Teeth With a Mixture of Calcium Hydroxide and Gingerols	N/A
Completed	`NCT04545307` - Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis	Phase 2/Phase 3
Recruiting	`NCT06142799` - Influence of Moment of Restoration in Pain After a Root Canal Treatment	N/A
Completed	`NCT06227533` - Comparison Between Two Regenerative Scaffolds	N/A
Not yet recruiting	`NCT05305417` - Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT)	N/A
Not yet recruiting	`NCT03504332` - Revascularization of Immature Anterior Necrotic Teeth	Phase 3
Completed	`NCT04390854` - Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth	Phase 2
Completed	`NCT03804450` - Magnetic Resonance Imaging (MRI) of Pulp Regeneration	Phase 2
Completed	`NCT05057325` - Post Operative Pain Assessment After Pulpectomy of Primary Molars With Two Different Rotary Systems	N/A
Completed	`NCT05964686` - The Efficacy of Laser in Root Canal Disinfection	Phase 2
Completed	`NCT06129643` - Post-operative Pain After Laser Root Canal Treatment of Necrotic Teeth With Apical Periodontitis	Phase 2
Terminated	`NCT04533074` - Microbiological Evaluation of Single Versus Multiple Visits Regeneration Using MALDI-TOF Mass Spectrometry	Phase 2
Active, not recruiting	`NCT06256250` - Assessment of Post-operative Pain After Different Instrumentation Techniques in Pulpectomy Treatment of Primary Molars	N/A
Completed	`NCT06173648` - Histopathological Evaluation of the Periodontal Ligament Subjected to Laser Ablation.	N/A
Not yet recruiting	`NCT05230797` - Zincoxide-propolis vs Zincoxide-eugenol Pulpectomy	Early Phase 1

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.