Clinical Trials Logo
  1. Home
  2. Pulp Necroses
  3. NCT05728346

The Efficacy and Safety of Pulp Regeneration Induced by SHED Polymerization

Pulp Necroses Clinical Trial

Official title:
A Single-arm Clinical Trial Evaluating the Efficacy and Safety of Pulp Regeneration Induced by SHED Polymerization in Patients With Pulp Necrosis of Permanent Teeth

Clinical Trial Summary

Dental pulp necrosis is one of the most common pathological conditions that results in tooth loss. However, regeneration of functional dental pulp has proved difficult. Therefore, the investigators conduct a single-arm study to evaluate the efficacy and safety of pulp regeneration induced by SHED mixed with hyaluronic acid polymerization in patients with pulp necrosis of permanent teeth.

Clinical Trial Description

This study is a single-center, prospective, single-arm study to evaluate the efficacy and safety of pulp regeneration induced by SHED mixed with hyaluronic acid polymerization in patients with pulp necrosis of permanent teeth. This study plans to include 30 subjects from the Department of Stomatology of the Fifth Affiliated Hospital of Guangzhou Medical University. All participants in this study will receive stem cells from human exfoliated deciduous teeth (SHED) mixed with hyaluronic acid polymers after the preparation and disinfection of the root canal of the affected teeth. All participants will undergo screening and baseline visits. After surgery, the participants will be followed up for 2 years. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05728346
Study type Interventional
Source Fifth Affiliated Hospital of Guangzhou Medical University
Contact
Status Not yet recruiting
Phase N/A
Start date September 1, 2023
Completion date September 30, 2026
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04035083 - Laser Activated Irrigation Versus Passive Ultrasonic Irrigation N/A
Completed NCT04638972 - Accuracy of Apex Locators in Primary Teeth
Completed NCT05181813 - Treatment of Infected Pulp in Primary Teeth With a Mixture of Calcium Hydroxide and Gingerols N/A
Completed NCT04545307 - Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis Phase 2/Phase 3
Recruiting NCT06142799 - Influence of Moment of Restoration in Pain After a Root Canal Treatment N/A
Completed NCT06227533 - Comparison Between Two Regenerative Scaffolds N/A
Not yet recruiting NCT05305417 - Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT) N/A
Not yet recruiting NCT03504332 - Revascularization of Immature Anterior Necrotic Teeth Phase 3
Completed NCT04390854 - Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth Phase 2
Completed NCT03804450 - Magnetic Resonance Imaging (MRI) of Pulp Regeneration Phase 2
Completed NCT05057325 - Post Operative Pain Assessment After Pulpectomy of Primary Molars With Two Different Rotary Systems N/A
Completed NCT06129643 - Post-operative Pain After Laser Root Canal Treatment of Necrotic Teeth With Apical Periodontitis Phase 2
Completed NCT05964686 - The Efficacy of Laser in Root Canal Disinfection Phase 2
Terminated NCT04533074 - Microbiological Evaluation of Single Versus Multiple Visits Regeneration Using MALDI-TOF Mass Spectrometry Phase 2
Active, not recruiting NCT06256250 - Assessment of Post-operative Pain After Different Instrumentation Techniques in Pulpectomy Treatment of Primary Molars N/A
Completed NCT06173648 - Histopathological Evaluation of the Periodontal Ligament Subjected to Laser Ablation. N/A
Not yet recruiting NCT05230797 - Zincoxide-propolis vs Zincoxide-eugenol Pulpectomy Early Phase 1