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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04842591
Other study ID # 33-022 ex 20/21
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date December 23, 2020
Est. completion date December 31, 2025

Study information

Verified date January 2024
Source Medical University of Graz
Contact Gabor Kovacs, MD
Phone +43-316-385-80748
Email gabor.kovacs@klinikum-graz.at
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.


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Study Design


Intervention

Diagnostic Test:
exercise echocardiography
All patients will undergo exercise echocardiography during a symptom-limited cardiopulmonary exercise test.

Locations

Country Name City State
Austria Medical University of Graz, Department of Internal Medicine, Division of Pulmonology Graz

Sponsors (2)

Lead Sponsor Collaborator
Medical University of Graz Janssen-Cilag G.m.b.H

Country where clinical trial is conducted

Austria, 

References & Publications (16)

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Outcome

Type Measure Description Time frame Safety issue
Primary Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope (calculated as the difference of maximal and resting SPAP divided by the difference of maximal and resting CO) before versus one year after kidney transplantation assessed by exercise echocardiography Baseline and 1 year after kidney transplantation
Secondary Change in systolic pulmonary arterial pressure at rest before versus one year after kidney transplantation assessed by (exercise) echocardiography Baseline and 1 year after kidney transplantation
Secondary Change in systolic pulmonary arterial pressure at 25 Watts before versus one year after kidney transplantation assessed by (exercise) echocardiography Baseline and 1 year after kidney transplantation
Secondary Change in mean pulmonary arterial pressure at rest before versus one year after kidney transplantation Baseline and 1 year after kidney transplantation
Secondary Change in mean pulmonary arterial pressure during exercise before versus one year after kidney transplantation Baseline and 1 year after kidney transplantation
Secondary Change in pulmonary vascular resistance at rest before versus one year after kidney transplantation Baseline and 1 year after kidney transplantation
Secondary Change in pulmonary vascular resistance during exercise before versus one year after kidney transplantation Baseline and 1 year after kidney transplantation
Secondary Change in pulmonary arterial wedge pressure at rest before versus one year after kidney transplantation Baseline and 1 year after kidney transplantation
Secondary Change in pulmonary arterial wedge pressure during exercise before versus one year after kidney transplantation Baseline and 1 year after kidney transplantation
Secondary Change in cardiac output at rest before versus one year after kidney transplantation Baseline and 1 year after kidney transplantation
Secondary Change in cardiac output during exercise before versus one year after kidney transplantation Baseline and 1 year after kidney transplantation
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