Pulmonary Hypertension Clinical Trial
Official title:
Acute Exposure to Hypoxia in Precapillary Pulmonary Hypertension: Physiological and Clinical Effects at Rest and During Exercise
Randomized crossover trial in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary Hypertension (CTEPH) to assess the acute response to simulated altitude (FiO2:15.1, equivalent to 2500m above sea level) on blood and tissue oxygenation (ABGA, near infrared spectroscopy)
Low altitude baseline measurements will be performed in Zurich (460m asl) including
Echocardiography, Right heart catheterization, six-minute walk test (6MWT), pulmonary
function test, clinical assessment and blood gas analysis.
Randomly assigned to the order of testing, the participants will be tested under simulated
altitude (FiO2: 15.1% with the "AMC altitrainer") and shamed altitude with the same device.
At rest and under exercise data from ABGA and near infrared spectroscopy will be compared
under simulated altitude and shamed altitude.
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