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Acute Exposure of Simulated Hypoxia on ECG and Non-invasive Blood Pressure

Pulmonary Hypertension Clinical Trial

Official title:
Acute Exposure to Hypoxia in Precapillary Pulmonary Hypertension: Physiological and Clinical Effects at Rest and During Exercise.

Clinical Trial Summary

Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FIO2: 15.1% = equivalent to 2500m above sea level) on ECG repolarizations and non-invasive blood pressure measurements by Finapres® NOVA Technology.

Clinical Trial Description

Low altitude baseline measurements will be performed in Zurich (469m asl) including Echocardiography, right heart catheterization, six Minute Walking test (6MWT), pulmonary function test, clinical assessment and blood gas analysis at rest and under exercise. Randomly assigned to the order of testing, the participants will e tested under simulated altitude (FiO2: 15.1% with the "AMC Altitrainer") and shamed altitude with the same device. During the exposure to simulated altitude (FiO2: 15.1%) and shamed altitude of 1 hour each, the participants' ECG and non-invasively assessed blood pressure by Finapres at rest and under exercise will be collected. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03581851
Study type Interventional
Source University of Zurich
Contact
Status Completed
Phase N/A
Start date July 1, 2018
Completion date April 1, 2019
View Details
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