Pulmonary Hypertension Clinical Trial
Official title:
Cardiac Magnetic Resonance Imaging and Pulmonary Perfusion: Its Role in the Diagnosis of the Severity of Pulmonary Hypertension in Adults and in the Follow-up. Preliminary Study.
Pulmonary hypertension is a rare severe disease leading to cardiac insufficiency. Treatment
depends on the severity of the disease.
This study evaluates cardiac MRI for the assessment of pulmonary hypertension severity and
identification of parameters useful for the follow-up in order to adapt the medical
treatment to status of the patient.
Evaluate if cardiac MRI can obviate right cardiac catheterization in the follow-up.
Thirty patients will be enrolled and followed for 1 year after their inclusion.
Cardiac MRI will be performed at inclusion and at 3 months and 12 months. At the same
periods, echocardiography and right heart catheterization will be performed too.
Morphological and functional parameters will be studied with MRI and correlated to invasive
parameters and echocardiography too.
Morphological parameters are: volumes, cardiac cavities areas and ratios and position of the
interventricular septum. Functional parameters are: ejection fractions of right and left
cavities, flow in pulmonary artery, across mitral and tricuspid valves, temporal
measurements in the pulmonary artery and auriculoventricular valves.
The invasive measurements are considered as the gold standard for this study. The
classification of the severity is defined according to the parameters from right cardiac
catheterization (4 grades with severity increasing between 1 and 4).
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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