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Pulmonary Emphysema clinical trials

View clinical trials related to Pulmonary Emphysema.

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NCT ID: NCT02827721 Recruiting - COPD Clinical Trials

Evaluation of Novel Lung Function Parameters in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Start date: July 2015
Phase:
Study type: Observational

Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of COPD.

NCT ID: NCT02823223 Active, not recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Endobronchial Valve in Patients With Heterogeneous Emphysema

Start date: June 2016
Phase: N/A
Study type: Interventional

To compare the clinical outcomes of Endoscopic Lung Volume Reduction using Pulmonx Zephyr Endobronchial Valve (EBV) vs. Standard of Care (SoC) in the treatment of heterogeneous emphysema patients in a controlled trial design setting.

NCT ID: NCT02810327 Completed - COPD Clinical Trials

Alpha-1 Carrier Genomics Study

Start date: February 2015
Phase:
Study type: Observational

The goal of this study is to better understand why some Alpha-1 genotype MZ (PiMZ) individuals develop chronic obstructive pulmonary disease (COPD) while others do not. This study will examine portions of the Alpha-1 gene that are not routinely tested to determine whether other changes in this gene correlate with development and progression of COPD. Participation involves responding to questionnaires about lung health and history, and performing an at-home finger stick to obtain blood spots using a test kit that is mailed. The blood provided will be used for genetic testing and correlation of results with COPD history. Participants will receive their results and access to genetic counseling at the conclusion of the study.

NCT ID: NCT02805699 Recruiting - Clinical trials for Combined Pulmonary Fibrosis and Emphysema

A Clinical Evaluation of Baofeikang Granule in Combined Pulmonary Fibrosis and Emphysema Treatment

Start date: June 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to confirm the efficacy and safety of BaofeiKang Granule in the treatment of Combined Pulmonary Fibrosis and Emphysema patients.

NCT ID: NCT02803242 Recruiting - Emphysema Clinical Trials

COPD Patient-Powered Research Network

COPD PPRN
Start date: August 2014
Phase:
Study type: Observational [Patient Registry]

The COPD Patient-Powered Research Network (COPD PPRN) is a patient research registry with the goal of enrolling 75,000 or more COPD patients and those at risk who are willing to share their heath information over several years and participate in research. The COPD PPRN has built an online platform to allow volunteers to enroll electronically, complete surveys, be contacted about studies they qualify for and become connected to COPD resources. The goal of the registry is to speed research to find better treatments for COPD and ultimately a cure.

NCT ID: NCT02796937 Enrolling by invitation - Clinical trials for Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency

Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency

SPARTA-OLE
Start date: July 2016
Phase: Phase 3
Study type: Interventional

This is a 2-year open-label, multicenter extension of the double-blind, placebo-controlled GTi1201 study. The purpose of this study is to obtain an additional 2 years of safety data for intravenously administered Alpha1-MP 60 mg/kg/week in subjects with alpha1-antitrypsin deficiency (AATD).

NCT ID: NCT02778802 Recruiting - Clinical trials for Pulmonary Hypertension

Pulmonary Hemodynamics in Patients With Severe Emphysema Pre and Post BLVR

Start date: June 2016
Phase: N/A
Study type: Observational

This study is designed as a prospective study, with the primary endpoint being changes in pulmonary hemodynamic parameters after ELVR in patients with severe emphysema. Secondary endpoints will be changes in lung function parameters, exercise capacity, and QoL.

NCT ID: NCT02719184 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease)

Start date: April 13, 2016
Phase:
Study type: Observational

The study will include 60 healthy subjects (ex-smoker without any airflow limitation), 125 COPD GOLD (global initiative for chronic obstructive lung disease) I , 125 COPD GOLD II, 125 COPD GOLD III and up to 20 patients with COPD and A1AT (Alpha1-Antitrypsin) deficiency (ZZ genotype). Soluble and imaging biomarkers will be investigated addressing different aspects of disease pathways postulated to be relevant for COPD progression.

NCT ID: NCT02696564 Completed - Emphysema Clinical Trials

Losartan Effects on Emphysema Progression

LEEP
Start date: May 23, 2017
Phase: Phase 4
Study type: Interventional

A randomized, parallel, placebo controlled trial to evaluate the effect of 100mg/day losartan on the progression of emphysema as measured by quantitative HRCT compared to placebo .

NCT ID: NCT02682147 Recruiting - Emphysema Clinical Trials

Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema

Start date: July 10, 2017
Phase: Phase 4
Study type: Interventional

This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking population. The investigators will correlate DECT measures of perfusion with lung injury measured by single photon emission computed tomography (SPECT). The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema