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Pulmonary Emphysema clinical trials

View clinical trials related to Pulmonary Emphysema.

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NCT ID: NCT03244059 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies

BOTEGA
Start date: August 9, 2018
Phase: Phase 2
Study type: Interventional

This is intended to be an initial "proof-of-concept" study to show feasibility, validate assays and approaches, and explore dosing and safety of belimumab in pulmonary emphysema patients who have clinically relevant (and quantifiable) autoimmune responses. The primary goal is to determine effects of belimumab on levels of autoantibodies against glucose regulated protein 78 (GRP78) among patients with pulmonary emphysema attributable to cigarette smoking. The investigators hypothesize that belimumab treatment will safely reduce circulating levels of autoantibodies that are associated with emphysema, and comorbidities of this lung disease, including atherosclerosis.

NCT ID: NCT03205826 Completed - Emphysema or COPD Clinical Trials

Chartis Collateral Ventilation Measurement: Conscious Sedation Versus General Anesthesia

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

Rationale: The Chartis® ( Pulmonx, CA, USA) measurement system is a tool to assess interlobar collateral ventilation during bronchoscopy. Assessing collateral ventilation is important when you intend to treat a patient with endobronchial valves. Chartis measurement of collateral ventilation can be performed under both conscious sedation as well as general anesthesia. There is no consensus on what is the preferred method of anesthesia for Chartis measurements in the literature. Objective: In this project we want to investigate whether there is a difference in Chartis measurement outcomes between these two methods of anesthesia: conscious sedation and general anesthesia. Study design: This study will be a single center observational study Study population: The study population exists of patients with severe emphysema who undergo collateral ventilation assessment before bronchoscopic lung volume reduction treatment with one-way endobronchial valves. Intervention: All patients will undergo two subsequent Chartis measurements. The first measurement will be performed with the patient undergoing conscious sedation and the second measurement with the patient under general anesthesia. Main study parameters/endpoints: Our primary outcome measure is the failure rate of the Chartis collateral ventilation measurement under general anesthesia versus conscious sedation.

NCT ID: NCT03114020 Completed - Emphysema Clinical Trials

Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency

Start date: March 22, 2017
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the safety and efficacy of administering repeated doses of Hyaluronic Acid Inhalation Solution to subjects with Emphysema that have Alpha-1-Antitrypsin deficiency

NCT ID: NCT03010566 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Lung Volume Reduction Coil Microbiome Study

LVRC-Micro
Start date: January 30, 2017
Phase:
Study type: Observational

Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema

NCT ID: NCT03010449 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves

BLOOD-VALVES
Start date: August 24, 2017
Phase: N/A
Study type: Interventional

A single arm pilot study of lung volume reduction in severe emphysema using bronchoscopic autologous blood instillation in combination with intra-bronchial valves.

NCT ID: NCT03008915 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency

Start date: January 2017
Phase: Phase 2
Study type: Interventional

The aim of this study is to test whether aspirin improves endothelial function in alpha-1 antitrypsin deficiency-associated lung disease, measured by pulmonary microvascular blood flow on magnetic resonance imaging (MRI) and with apoptotic endothelial microparticles.

NCT ID: NCT03008226 Recruiting - Emphysema Clinical Trials

Spiration Valve System 9 mm European Post Market Evaluation Study

Start date: June 2015
Phase: N/A
Study type: Observational

The purpose of this observational study is to investigate the efficacy of 9 mm intrabronchial valve treatment in patients with heterogeneous emphysema and to gain further insights and experience on the treatment with this valve size.

NCT ID: NCT02914340 Completed - Emphysema Clinical Trials

REACH SVS Control Patient Cross-Over Study

Start date: September 2016
Phase: N/A
Study type: Interventional

This is a multicenter, prospective study designed to evaluate performance of the SVS in the REACH SVS control patients. The study is expected to enroll up to 20 patients at up to 12 sites with up to 6 patients per site.

NCT ID: NCT02879331 Recruiting - Pulmonary Emphysema Clinical Trials

Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils

CYCLONE
Start date: November 2016
Phase: N/A
Study type: Interventional

The study hypothesis is that patients with homogeneous emphysema behave differently compared to heterogeneous emphysema with respect to exercise capacity. A better understanding of this difference will allow the investigators to choose the best treatment for each type of patient. The main purpose of this study is to evaluate the change in exercise capacity measured by cycle ergometry in patients with severe emphysema after endoscopic lung volume reduction with coils (eLVR). As a secondary purpose, the investigators want to perform an exploratory, randomized study to compare the results of two different therapeutic approaches in a small sample of patients with homogeneous emphysema.

NCT ID: NCT02835001 Terminated - Emphysema Clinical Trials

Hyperinflation Assessment After Treatment by Lung Volume Reduction Coil

HEAT-LVRC
Start date: January 15, 2019
Phase: N/A
Study type: Interventional

Hyperinflation Assessment After Treatment by Lung Volume Reduction Coil (HEAT-LVRC) on Hyperinflation in Severe Emphysema