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Pulmonary Emphysema clinical trials

View clinical trials related to Pulmonary Emphysema.

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NCT ID: NCT01796392 Completed - Emphysema Clinical Trials

Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)

LIBERATE
Start date: July 2013
Phase: N/A
Study type: Interventional

The purpose of this research is to study an investigational medical device that is designed to produce lung volume reduction in diseased areas of the lungs in patients with severe emphysema.

NCT ID: NCT01758055 Not yet recruiting - Emphysema Clinical Trials

Safety Study of Endobronchial Transplantation of Autologous Mesenchymal Stem Cells (MSCs) in Emphysema Patients

Start date: December 2012
Phase: Phase 1
Study type: Interventional

The purpose of this study is evaluating the safety of endobronchial transplantation of autologous mesenchymal stem cells derived bone marrow in patients with emphysema.

NCT ID: NCT01744093 Completed - HIV Clinical Trials

Doxycycline for COPD in HIV-Infected Patients

Start date: December 8, 2014
Phase: N/A
Study type: Interventional

In the context of improved survival from HIV infection itself, chronic obstructive pulmonary disease (COPD); a form of lung disease that includes emphysema, which makes breathing difficult) is emerging as an important cause of morbidity and perhaps ultimately mortality in this population. HIV-infected patients are at increased risk of chronic obstructive pulmonary disease, likely due to multiple factors, including an increased presence of smoking, chronic inflammation and progression of immunodeficiency, oxidant stress (excessive levels of natural chemicals called oxidants and free radicals that can damage tissue), and respiratory infections. While natural history data on COPD are limited in the era of potent antiretroviral therapy, earlier data suggest that the course of emphysema may be accelerated in this population. Our preliminary data suggest that several matrix metalloproteinases (MMPs) derived from alveolar macrophages (a type of immune cell found in the lungs) have an increased cellular response in HIV-infected smokers, which could contribute to accelerated emphysema. Matrix metalloproteinases are enzymes that break down the structural support of tissues, including the airways in the lung. Based on these observations, the investigators hypothesize that pharmacologic inhibition of matrix metalloproteinases by doxycycline will favorably modify the natural history of chronic obstructive pulmonary disease in HIV-infected patients. To test this hypothesis, the investigators propose conducting a proof of concept pilot study as a prelude to a possible phase II randomized, placebo-controlled trial (testing safety and efficacy in a larger population controlled with a "sugar pill") of doxycycline for COPD in HIV-infected patients should the proof of concept be successful. Our research team is lead by a pulmonologist/researcher with expertise in HIV-associated COPD and an infectious diseases specialist/clinical trials expert.

NCT ID: NCT01728662 Not yet recruiting - Clinical trials for Patients With Advanced Homogeneous Emphysema

Emphysematous Lung Sealant Therapy in Homogeneous Emphysema

Start date: December 2012
Phase: N/A
Study type: Interventional

This study will test that hypothesis that endoscopic lung volume reduction therapy performed using emphysematous lung sealant treatment can be improved using smaller doses delivered to more a larger number of treatment sites.

NCT ID: NCT01727037 Recruiting - Bullous Emphysema Clinical Trials

Bronchoscopic Intrabullous Autologous Blood Instillation (BIABI) for Emphysema

BIABI
Start date: October 2012
Phase: Phase 2
Study type: Interventional

Patients with large bullae (large empty air sacs in the lung) may benefit from bullectomy (surgery to resect these bullae), however this is a major surgery with significant potential morbidity and long hospital stays. Many patients are not well enough to have this surgery, or may not wish to have it. A less invasive means of attempting to shrink the size of the bullae is to directly inject the patients' own blood into the bullae (we believe that this can lead to an inflammatory reaction leading to gradual scarring and volume loss). This can be performed bronchoscopically in a 20-30 minute procedure using conscious sedation (avoiding general anaesthesia). The aim of this study is to assess the effects on lung function, quality of life measures, functional measures and CT measured lung volumes of bronchoscopic intrabullous blood instillation in patients with bullous emphysema.

NCT ID: NCT01719263 Completed - Emphysema Clinical Trials

Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study

Start date: June 2013
Phase: N/A
Study type: Interventional

This study is designed to demonstrate safety and efficacy in patients with severe upper lobe predominant emphysema. For validity of the study, the results will be compared to patients that receive optimal medical therapy.

NCT ID: NCT01710449 Completed - Asthma Clinical Trials

Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen

Start date: September 2009
Phase: Phase 1
Study type: Interventional

An open label study in 40-60 subjects with diagnosed lung airway disease and in 10-20 normal controls. Each subject will receive PFP as a contrast agent to visualize the airway and alveolar spaces in their lungs using magnetic resonance imaging of inert gas/oxygen mixtures.

NCT ID: NCT01682850 Completed - Lung Cancer Clinical Trials

Pulmonary Rehabilitation Before Lung Cancer Resection

Start date: August 2013
Phase: N/A
Study type: Interventional

This study seeks to study the effectiveness of a short mindfulness based pulmonary rehabilitation program prior to a surgical resection in patients with lung cancer and severe Chronic Obstructive Lung Disease (COPD).

NCT ID: NCT01615484 Completed - Cystic Fibrosis Clinical Trials

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability

Start date: September 2013
Phase: N/A
Study type: Interventional

The purpose of this research study is to learn about the safety of transplanting lungs obtained from non-heart-beating donors (NHBDs) that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and perfused with a lung perfusion solution (Steen solution™, made by Vitrolife). This ventilation and perfusion will be done outside the body (ex-vivo) in a modified cardiopulmonary bypass circuit (the kind of device used routinely during most heart surgeries). The purpose of performing ex-vivo perfusion and ventilation is to learn how well the lungs work, and whether they are likely safe to transplant.

NCT ID: NCT01608490 Terminated - Emphysema Clinical Trials

Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) Study

RENEW
Start date: October 2012
Phase: N/A
Study type: Interventional

Multicenter, randomized, assessor-blinded controlled study of safety and effectiveness of the PneumRx, Inc. RePneu Lung Volume Reduction Coil (RePneu LVRC) System