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Pulmonary Disease clinical trials

View clinical trials related to Pulmonary Disease.

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NCT ID: NCT06185842 Active, not recruiting - Pulmonary Disease Clinical Trials

The Effectiveness of a Lung Health Promotion Program Based on the 5A Self Management Support Model.

Start date: November 24, 2023
Phase: N/A
Study type: Interventional

This research will be conducted to examine the effect of the lung health promotion program based on the 5A self-management support model on some physiological parameters, Physical Activity Scale in the Elderly score, sleep quality, health status perception and vaccination status of adults aged 65 and over. The research will be carried out as a randomized controlled study with a parallel design. We estimate that the respiratory functions of the elderly will improve, their physical activity levels will increase, immunization against common infectious diseases will increase and people's health perceptions will improve. with the lung health promotion program based on the 5A self-management support model.

NCT ID: NCT05404815 Active, not recruiting - Preterm Birth Clinical Trials

Exposure to Plasticisers in the Neonatal Intensive Care Unit

PLASTIC-NICU
Start date: June 2, 2020
Phase:
Study type: Observational

Neonatal intensive care relies on indwelling plastic medical devices fundamental in respiratory support, intravenous catheterization, and nutrition. While being in a critical developmental period, constant exposure to these invasive medical devices puts premature neonates at risk of plasticizers' potential toxicity. Despite novel regulations and development of alternative plasticizers (AP), reference to guide manufacturers and an overview of the prevailing exposure levels to DEHP or alternatives in the neonatal intensive care unit (NICU) are still missing. The three main objectives of this project are: (1) to assess current exposure to plasticizers in the NICU, (2) to identify the sources of exposure and (3) to study the resultant long-term health risk in premature neonates. These objectives are addressed in three work packages (WP). In work package 1, in vivo exposure of premature neonates to phthalates and alternative plasticizers is assessed by determining their metabolites in biological matrices (urine and hair). Work package 2 explores ex vivo leaching characteristics of different plasticizers from medical devices used in the NICU. Finally, Work package 3 studies the long-term neurocognitive and lung development in relation to plasticizer exposure in the NICU.

NCT ID: NCT05378139 Active, not recruiting - Cardiac Disease Clinical Trials

Continuous Wireless Monitoring of Vital Signs and Automated Alerts in Hospitalized Patients

Start date: February 1, 2021
Phase:
Study type: Observational

The primary aim of this study is to test and assess the implementation and effectiveness of continuous wireless vital signs monitoring with real-time alerts on: The frequency of patients monitored with adequate data quality as adequate clinical user satisfaction in the initial versus the last part of the trial (primary outcome).

NCT ID: NCT05300347 Active, not recruiting - Bronchiectasis Clinical Trials

Observational Study Evaluating the Prevalence of Enzyme Deficiency in Pulmonology Clinics (ADA)

Start date: June 17, 2021
Phase:
Study type: Observational

This observational study was designed as a prospective epidemiological screening study. Patients who applied to the centers participating in the study, bronchiectasis was detected on at least one computed tomography of the lungs; Immunoglobulin E height and/or were found to be lymphopenic on at least one examination will be included in the study. Up-to-date data will be collected from patients who have agreed to participate in the study, and a blood sample with DBS will be taken from patients. The blood taken will be subjected to analysis for ADA metabolites. For patients with a high metabolic test, the responsible researcher will advise on clarifying the diagnosis with a genetic test other than the study. In case of formation of new information for each patient, consultation will be provided by the responsible researcher. Thus, the prevalence of ADA enzyme deficiency disease in patients with bronchiectasis, Immunoglobulin E elevation and/or lymphopenia will be evaluated. In addition, with this study, it will be scientifically demonstrated whether lymphopenia and/or Immunoglobulin E height is a parameter that facilitates the early diagnosis of patients with late-onset ADA enzyme deficiency.

NCT ID: NCT04681508 Active, not recruiting - Acute Kidney Injury Clinical Trials

MINS, AKI and Pulmonary Pathology in Patients Undergoing Acute Abdominal Surgery

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

Explorative study to investigate potential predictors of myocardial injury, acute kidney injury and pulmonary disorder after acute high-risk abdominal surgery.

NCT ID: NCT04669444 Active, not recruiting - Critical Illness Clinical Trials

Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients

IGNITE
Start date: April 14, 2020
Phase: N/A
Study type: Interventional

Patients in end-stage cardiac failure and/or respiratory failure may be started on a rescue therapy known as Extracorporeal Membrane Oxygenation (ECMO). One of the major clinical questions is how to manage the ventilator when patients are on ECMO therapy. Ventilator Induced Lung Injury (VILI) can result from aggressive ventilation of the lung during critical illness. VILI and lung injury such as Acute Respiratory Distress Syndrome (ARDS) can further increase the total body inflammation and stress, this is known as biotrauma. Biotrauma is one of the mechanisms that causes multi-organ failure in critically ill patients. One advantage of ECMO is the ability to greatly reduce the use of the ventilator and thus VILI by taking control of the patient's oxygenation and acid-base status. By minimizing VILI during ECMO we can reduce biotrauma and thus multi-organ failure. Since the optimal ventilator settings for ECMO patients are not known, we plan to study the impact of different ventilator settings during ECMO on patient's physiology and biomarkers of inflammation and injury.

NCT ID: NCT04554225 Active, not recruiting - Pulmonary Disease Clinical Trials

Pulmonary Disease Requiring Ambulatory Oxygen Therapy -Resilience and Quality of Life

koti-happi
Start date: November 1, 2017
Phase:
Study type: Observational

Dyspnea is common symptom in pulmonary diseases, like chronic obstructive pulmonary disease (COPD) or other pulmonary disease. Ambulatory oxygen therapy is often prescribed to these patients. In these patients resilience, health related quality of life, life satisfaction are measured and the effect and patient satisfaction to ambulatory oxygen therapy are studied.

NCT ID: NCT04165564 Active, not recruiting - Pulmonary Disease Clinical Trials

DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers

Start date: August 24, 2020
Phase:
Study type: Observational

DECAMP 1 PLUS aims to improve the efficiency of the diagnostic evaluation of patients with indeterminate pulmonary nodules (8-25 mm). Molecular biomarkers for lung cancer diagnosis measured in minimally invasive and non-invasive biospecimens may be able to distinguish between malignant or benign indeterminate pulmonary nodules in high-risk smokers. Ultimately, this study aims to validate molecular as well as clinical and imaging biomarkers of lung cancer in individuals with indeterminate lung nodules.

NCT ID: NCT03572335 Active, not recruiting - HIV Infections Clinical Trials

Systems Biology of Diffusion Impairment in Human Immunodeficiency Virus (HIV)

BoDI
Start date: September 6, 2018
Phase:
Study type: Observational

Diffusing capacity for carbon monoxide (DLco) abnormalities are common in HIV+ individuals and associated with significant morbidity and mortality. The complexity and the individualized differences in causes of these abnormalities have been challenging to unravel using traditional approaches. In this proposal, the investigators construct a systems' modeling approach to identify novel molecular and clinical pathways contributing to DLco impairment in HIV+ individuals and to determine predictive signatures of DLco decline in order to develop strategies to treat and prevent abnormal lung function in this susceptible population.

NCT ID: NCT03395093 Active, not recruiting - Pulmonary Disease Clinical Trials

BIS of Sedation Depth During Flexible Bronchoscopy.

BIS
Start date: July 21, 2016
Phase: N/A
Study type: Interventional

Fentanyl is analgesia medication. There has not pain nerve in the lung. Flexible bronchoscopy(FB) is used in the respiratory medicine. So people will not feel pain in the process of FB. The purpose of the study is to know if Fentanyl is useful in the conscious sedation of FB.