Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
Impact of Viral Infections in Patients With Chronic Obstructive Pulmonary Diseases: Virological Work-up During Exacerbations and 1-year Follow-up
The objectives of the study are
- to determine the prevalence of respiratory virus infections in COPD patients, during
and outside acute exacerbation
- to explore the impact of these viral infections on the outcome of these patients
- to explore the association between blood procalcitonin levels and viral infections in
this population.
Background
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity due to repeated
exacerbations. The impact of viral infections during and outside COPD exacerbations is
poorly understood and there is only scarce data on the role of new biological markers of
infection for the management of COPD exacerbations.
Objectives of the project
The investigators aim to
1. describe the epidemiology of viral infections in patients admitted with an exacerbation
of their COPD;
2. explore the evolution of viral infections outside exacerbations;
3. analyze the impact of viral infections on clinical outcomes;
4. explore the role of biological markers (CRP, procalcitonin) for the diagnosis and
prognosis of viral infections.
Methods
The investigators will prospectively follow-up 100 patients admitted with an acute
exacerbation of their COPD. Virological samples will be obtained at admission and at 3
months, to explore the evolution outside episodes of acute exacerbation. Clinical
information will be obtained after one-year follow-up. Samples will be tested by RT-PCR for
15 respiratory viruses. The impact of viral infections and the role of biological markers
will be explored using univariate and multivariate Cox proportional hazard models.
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Observational Model: Cohort, Time Perspective: Prospective
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