Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
Modification of Chronic Inflammation by Inhaled Carbon Monoxide in Patients With Stable COPD
The purpose of this study is to determine whether carbon monoxide is effective in the treatment of stable COPD.
COPD is characterised by a chronic pulmonary inflammation and a shifted oxidant/antioxidant
balance. The main cause of this inflammation is smoking. After smoking cessation, this
inflammation and shifted oxidant/antioxidant balance continues. This causes an increased
deterioration of lung function compared to healthy persons of matching age.
The ongoing inflammation appears to be relatively insensitive to corticosteroid therapy.
Until now, there is no therapy for this inflammation. Both in vitro and in vivo studies show
that carbon monoxide has, besides an antioxidant capacity, anti-inflammatory properties. The
aim of this trial is to study whether the inflammation can be reduced by inhalation of
carbon monoxide.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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