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Pulmonary Complications clinical trials

View clinical trials related to Pulmonary Complications.

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NCT ID: NCT04700215 Recruiting - Clinical trials for Pulmonary Complications

Comparison of BiPAP and ٰIS in Reducing Post CABG Pulmonary Complications

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

To evaluate the effect of Bi-level Positive Airway Pressure (BiPAP) and Incentive Spirometry (IS) in post CABG patients.

NCT ID: NCT03288558 Recruiting - Cardiac Surgery Clinical Trials

Protective Mechanical VENTilation Strategy in Patients Undergoing CARDiac Surgery

Start date: July 7, 2017
Phase: N/A
Study type: Interventional

Heart surgery is a life-saving intervention for hundreds of thousands of patients each year worldwide. Advances in technology and medical expertise have improved outcomes for these patients over the years. However, despite such advances, approximately 30% of patients develop lung complications (also called "pulmonary complications") after heart surgery, which result in prolonged hospital stay, increased mortality and healthcare costs. During and immediately after heart surgery, the patient's breathing needs to be artificially controlled by a breathing machine, called "mechanical ventilator". The medical literature has reported that in critically ill patients the use of specific settings on the breathing machine (so called "protective mechanical ventilation") prevents lung complications and significantly decreases mortality. Studies show that such settings could also be beneficial for patients that undergo several types of planned surgery, however data regarding heart surgery patients (the most vulnerable to lung complications) are lacking.The aim of our study is to test whether the use of protective mechanical ventilation settings during and after heart surgery reduces lung complications compared to the current standard of care. The main innovation of this study is the application of a novel protective mechanical ventilation strategy to patients undergoing cardiac surgery, in order to reduce post-operative pulmonary complications.

NCT ID: NCT02931409 Completed - Clinical trials for Inflammatory Response

Intraoperative PEEP Optimization: Effects on Postoperative Pulmonary Complications and Inflammatory Response

Start date: October 2016
Phase: N/A
Study type: Interventional

The purpose of this prospective randomized controlled trial is to determine the effects of intraoperative lung protective mechanical ventilation using an individual optimal PEEP value on postoperative pulmonary complications and inflammatory response. A total number of 40 patients undergoing open radical cystectomy and urinary diversion will be enrolled and randomized into two groups. Standard lung protective ventilation using a PEEP of 6 cmH2O will be performed in control group and an optimal PEEP value determined during a static pulmonary compliance (Cstat) directed PEEP titration procedure will be applyed in study group. Low tidal volumes (6mL/Kg IBW) and a fraction of inspired oxygen (FiO2) of 0.5 will be applyed in both groups. Procalcitonin kinetics will be monitored during and after surgery until the third postoperative day as well as postoperative pulmonary complications. Clinical condition and extrapulmonary complications will be evaluated by the Sequential Organ Failure Assessment (SOFA) Score and in-hospital stay, 28-days and in-hospital mortality will also be followed.

NCT ID: NCT02894879 Recruiting - Clinical trials for Pulmonary Complications

Effectiveness Of Modified Chest PT Technidue In Pre And Post-Operative Program In Patients Open Heart Surgery

Start date: September 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to explore effectiveness of modified chest physical therapy techniques using new device in pre and post-operative program in patients undergoing open heart surgery

NCT ID: NCT02825576 Terminated - Clinical trials for Pulmonary Complications

Prevention of Postoperative Events Following Reversal With Sugammadex or Neostigmine

P-PERSON
Start date: December 3, 2018
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if the use of sugammadex (compared with neostigmine) reduces the rate of postoperative pulmonary complications (PPCs).

NCT ID: NCT02739841 Completed - Clinical trials for Pulmonary Complications

Hemodynamic Responses to Ventilator Hyperinflation Technique

Start date: April 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to explore acute hemodynamic responses to VHI technique in critical traumatic patients with pulmonary complications in the intensive care unit.

NCT ID: NCT02627742 Completed - Atelectasis Clinical Trials

Evaluation of The MetaNeb® System to Reduce Postoperative Pulmonary Complications

Start date: March 2016
Phase: N/A
Study type: Interventional

To determine if a therapy regimen including treatment with The MetaNeb® System had a positive impact on the rate of pulmonary complications related to atelectasis and/or secretion retention that occur in high risk post-operative patients. This is a non-randomized facility (or hospital) level pre-post intervention study.

NCT ID: NCT02373475 Completed - Clinical trials for Pulmonary Complications

Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position

Start date: February 2015
Phase: Phase 4
Study type: Interventional

Postoperative pulmonary complications are main cause of overall perioperative morbidity and mortality in the patients following general anesthesia. A protective ventilation strategy refers to the use of low VT (in the range of 4-8 ml/kg of the predicted body weight) with positive end-expiratory pressure (PEEP), with or without recruitment maneuver. Protective ventilation has been considered the optimal practice in patients suffering from the acute respiratory distress syndrome (ARDS). However, few human studies have assessed how to ventilate healthy lungs in patients undergoing general anesthesia, especially in prone position. Prior studies reported that in the patients undergoing major abdominal surgery in supine position, intraoperative lung protective ventilator settings had the potential to protect against pulmonary complications. Therefore, the investigators planned this study to better specify the effect of intraoperative protective ventilation in surgical patients in the prone position.

NCT ID: NCT02017925 Withdrawn - Fatigue Clinical Trials

Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Cancer Undergoing Chemoradiation

Start date: October 2013
Phase: N/A
Study type: Interventional

This randomized clinical trial studies pulmonary rehabilitation in improving lung function in patients with locally advanced non-small cell lung cancer undergoing chemoradiation. Individualized exercise rehabilitation programs may reduce breathing problems and improve quality of life in patients with non-small cell lung cancer. It is not yet known whether pulmonary rehabilitation is more effective when started during or after cancer treatment.

NCT ID: NCT01285648 Completed - Lung Cancer Clinical Trials

Study of CPAP as Intervention After Lung Resection

CPAP
Start date: November 2007
Phase: N/A
Study type: Interventional

The aim of this study was to compare the oxygenation index (OI), dyspnea, and pain scale and evaluate the duration of thoracic drainage and pleural air leaks after lung resection in two groups of patients: chest physiotherapy (CP) patients and combined CP and Continuous Positive Airway Pressure (CPAP) patients.