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Pulmonary Atelectasis clinical trials

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NCT ID: NCT06072885 Recruiting - Clinical trials for Postoperative Pulmonary Atelectasis

Evaluation of Perioperative Lung Ultrasound Scores in Laparoscopic Pediatric Surgeries

Start date: October 15, 2023
Phase:
Study type: Observational

Laparoscopic surgeries require carbon-dioxide into the abdomen which may occasionally lead to atelectasis. The extent of this atelectasis is not well documented in peri-operative period although it has been extensively researched in critical care set up. In this study, it is aimed to observe the ultrasonographic condition of lungs in laparoscopic pediatric surgeries. The hypothesis was the Lung Ultrasound Scores would worsen in those surgeries by the end of the operation. Aged between 1-18 years pediatric patients who are scheduled for laparoscopic surgeries will be included in the study to observe the changes in the lung visuals throughout the operation. For that, after safe endotracheal intubation first ultrasonography will be performed for the first (T1) time, and the second ultrasonography will be performed once the surgery is finished and before extubation (T2). Lastly, the third evaluation will be performed after 30 minutes in post anesthesia care unit (T3). Lung Ultrasound Score (LUS) is calculated as follows: Both hemi-thoraxes are divided into 6 different zones, and depending on the number of B-lines, which happens due to aeration loss in lung tissue, every zone is scored. If there is no B-line, it is zero points. If the B-lines in the visual lower than 4, the area is scored as 1 point. The areas with B-lines more than 3 is scored as 2 points. Furthermore, if there is any disruption on the pleural face, then the area is scored as 3 points. Accordingly, the worst case scenario refers 36 points, meaning the less the points the better the lung aeration. Primary outcome is defined as T2 LUS which will show the actual condition of at the end of the surgery. For that, T1 scores and T2 scores will be compared. The secondary outcomes include T3 LUS, (T3-T1)LUS, intraoperative hemodynamics, length of stay in Post Anesthesia Care Unite, postoperative aldrete scores for discharging to ward, and intraoperative ventilation variables.

NCT ID: NCT06021249 Recruiting - Atelectasis Clinical Trials

Comparing Innovative and Traditional Ventilation Strategies on Atelectasis and Prognosis in Elderly Patients

Start date: September 28, 2021
Phase: N/A
Study type: Interventional

This study was divided into two parts, taking elderly patients undergoing general anesthesia surgery as the research subjects, through factorial design: 1. It was verified that in elderly patients undergoing general anesthesia surgery, innovative lung-protective ventilation strategies can reduce the occurrence of atelectasis and reduce the incidence of ventilator-related lung injury and postoperative pulmonary complications more than traditional lung-protective ventilation strategies; 2. On the basis of part one study proving that innovative lung-protective ventilation strategies can reduce the incidence of postoperative atelectasis and other complications in elderly patients undergoing general anesthesia surgery compared with traditional lung-protective ventilation strategies, further comparisons were made between the two factors of "positive pressure extubation" and "improved early postoperative respiratory training" in the innovative lung protective ventilation strategy, and whether there was an interaction between the two.

NCT ID: NCT06013098 Recruiting - Clinical trials for Atelectasis, Postoperative

Effects of Different Oxygen Concentrations on Pulmonary Complications in Patients Undergoing Radical Resection of Esophageal Cancer

DOICA-E
Start date: September 6, 2023
Phase: Phase 4
Study type: Interventional

Radical operation of esophageal cancer is complicated and traumatic, and ventilation with one lung in lateral position and ventilation with both lungs after supine position requires long-term tracheal intubation and ventilator-assisted ventilation, and the incidence of postoperative pulmonary complications is high.

NCT ID: NCT05873998 Recruiting - Atelectasis Clinical Trials

Detecting Lung's Closing Pressure by Capnography

Start date: February 28, 2023
Phase:
Study type: Observational

General anesthesia is associated with loss of pulmonary functional residual capacity and the consequent development of atelectasis and closure of the small airway. Mechanical ventilation in a lung with reduced functional residual capacity and atelectasis increased the dynamic alveolar stress-strain, inducing a local inflammatory response in atelectatic lung areas known as ventilatory-induced lung injury. This phenomenon may appear even in healthy patients undergoing general anesthesia and predisposes them to hypoxemic episodes that can persist in the early postoperative period. Lung recruitment maneuvers restore the functional residual capacity and, therefore, protect the lungs from lung injury. A key issue in this kind of treatment is detecting the lung's closing pressure in order to maintain the end-expiratory pressure above such a limit.

NCT ID: NCT05821114 Recruiting - Clinical trials for Atelectasis, Postoperative Pulmonary

End-Expiratory Lung Volume in Children Awakening From Propofol Anesthesia

Start date: April 7, 2023
Phase: N/A
Study type: Interventional

The goal of this pilot randomized clinical trial is to test the effects of high flow nasal oxygen and head elevation during awakening from propofol anesthesia in pediatric patients undergoing airway surgery. The main question[s] it aims to answer are: - High flow oxygen can decrease the occurence of atelectasis during awakening from propofol anesthesia in pediatric patients? - Head elevation can decrease the occurence of atelectasis during awakening from propofol anesthesia in pediatric patients? Researchers will compare high flow oxygen vs low flow oxygen group to see if the use of high flow oxygen decrease the occurence of atelectasis during awakening from propofol anesthesia. And in each group, the patients will be assigned to supine position vs head elevation position to compare the effects of head elevation during awakening from propofol anesthesia.

NCT ID: NCT05718284 Recruiting - Esophageal Cancer Clinical Trials

High Flow Nasal Cannula After Esophagectomy

OSSIGENA1V
Start date: April 1, 2023
Phase: N/A
Study type: Interventional

This study will compare the effect of HFNC versus standard oxygen administration after elective esophagectomy for cancer.

NCT ID: NCT05714033 Recruiting - Lung Clinical Trials

A Randomized Trial Comparing a Ventilatory Strategy To Prevent Atelectasis Versus a Lateral Decubitus Strategy During Robotic Bronchoscopy (VESPA vs. LADS Trial)

Start date: February 10, 2023
Phase: N/A
Study type: Interventional

To learn if LADS is better than VESPA at preventing atelectasis during a robotic bronchoscopy.

NCT ID: NCT05713929 Recruiting - Clinical trials for Gynecologic Surgical Procedures

Study of Atelectasis by Electrical Impedance Tomography

Start date: February 6, 2023
Phase: N/A
Study type: Interventional

The goal of this interventional study is to learn about the effects of different positions on the occurrence, regional distribution and reversibility of atelectasis by using a PulmoVista 500 monitor (Dräger. 23542 Lübeck), during general anesthesia with mechanical ventilation. The main questions it aims to answer are: - The increase in atelectasis after induction of general anesthesia in supine and Trendelenburg position compared with baseline (spontaneous breathing) - The eventual possibility of reversal of atelectasis caused by general anesthesia and Trendelenburg position by reverse Trendelenburg position and recruitment manÅ“uvre. Participants will be adult, autonomous and able to express their will, undergoing elective gynecological or urological surgery in the extended Trendelenburg position.

NCT ID: NCT05710419 Recruiting - Pneumonia Clinical Trials

Effects of Invasive Mechanical Ventilation on the Right Ventricular Function

Start date: November 4, 2022
Phase:
Study type: Observational

The goal of this observational study is to learn about the influence of mechanical ventilation on the right ventricular (RV) function. The primary focus is on methods which are routinely used to improve gas exchange in ventilated patients (positive end expiratory pressure [PEEP], inhalation of NO, prone positioning). The main questions it aims to answer are: - Effects of prone positioning, PEEP and inhalation of NO on RV-function - Are there determinants (clinical, laboratory, demographic, echocardiographic) for the right ventricular response to the above? RV-Function will be assessed with right ventricular pressure-volume loops recorded with a conductance catheter at - each PEEP-Level during titration of the best PEEP - before and every 5 minutes (for max. 45 minutes) after rotation to prone position - before and under continuous inhalation of NO (if required based on clinical grounds)

NCT ID: NCT05670483 Recruiting - Morbid Obesity Clinical Trials

Use of Airway Pressure Release Ventilation in Morbidly Obese Patients Undergoing Open Heart Surgery

Start date: December 3, 2022
Phase: N/A
Study type: Interventional

The goal of this Randomized Clinical trial is to to investigate if the use of Air Pressure Release Ventilation in morbidly obese patients undergoing open heart surgery will improve post operative pulmonary outcomes 60 Patients will be randomized into two groups according to the mode of ventilation used into: Group A: airway pressure release ventilation (APRV) group (30 Patients) Group B: Standard (control) group (30 Patients) Post-operatively, Patients will be ventilated with conventional Synchronized Intermittent Mandatory Ventilation (SIMV) volume control mode