Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
The relationship between absolute values of hepcidin levels and BMPR2 expression |
assessed as correlation between BMPR2 expression levels and hepcidin levels |
at enrollment |
|
Primary |
The relationship between hepcidin levels and BMPR2 expression |
analysis of differences of hepcidin levels in BMPR2 mutation carriers and non-carriers (BMPR2 mutation carriers are assumed to have a lower expression level of BMPR2) |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with ferritin levels |
Ferritin levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with transferrin levels |
Transferrin levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with soluble transferrin receptor saturation and concentration |
Soluble transferrin receptor saturation and concentration |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with iron levels |
Iron levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with red blood distribution cell width |
Red blood distribution cell width |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with erythroferrone levels |
Erythroferrone levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with hemoglobin levels |
Hemoglobin levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with hematocrit |
Hematocrit |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with erythropoietin (EPO) levels |
Erythropoietin (EPO) levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with C-reactive protein levels |
C-reactive protein levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with interleukin 6 (IL6) levels |
Interleukin 6 (IL6) levels to approximate inflammation |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with NT-proBNP levels |
NT-proBNP levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with BMP2 messenger ribonucleid acid (mRNA) expression levels |
BMP2 mRNA expression levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with BMP6 messenger ribonucleid acid (mRNA) expression levels |
BMP6 mRNA expression levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with overall transcriptomic analysis in blood samples and formalin fixed human PAH lung tissue samples |
overall transcriptomic analysis in blood samples and formalin fixed human PAH lung tissue samples |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with BMPR2 protein levels |
BMPR2 protein levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with BMP2 protein levels |
BMP2 protein levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with BMP6 protein levels |
BMP6 protein levels |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with 6-minute walking distance (6-MWD) |
6-minute walking distance (6-MWD) |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with BORG Scale of 6-minute walking distance (6-MWD) |
Borg Scale of 6-minute walking distance (6-MWD) |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with WHO functional class |
WHO functional class |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with forced vital capacity (FVC) |
forced vital capacity (FVC) |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with forced expiratory volume in one second (FEV1) |
forced expiratory volume in one second (FEV1) |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with forced expiratory flow (FEV) |
forced expiratory flow (FEV) |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with total lung capacity (TLC) |
total lung capacity (TLC) |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with diffusion-limited carbon monoxide (DLCo) |
diffusion-limited carbon monoxide (DLCo) |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with residual volume |
residual volume, normally accounting for about 25% of total lung capacity |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with blood gas analysis including partial pressure of oxygen |
partial pressure of oxygen |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with blood gas analysis including partial pressure of carbon dioxide |
partial pressure of carbon dioxide |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with blood gas analysis including oxygen saturation |
oxygen saturation |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with blood gas analysis including supplemental oxygen "yes" or "no" |
supplemental oxygen "yes" or "no" |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with cardiac output (CO) |
cardiac output (CO) measured by right heart catheterization |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with cardiac index (CI) |
cardiac index (CI) measured by right heart catheterization |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with pulmonary capillary wedge pressure (PAWP) |
pulmonary capillary wedge pressure (PAWP) measured by right heart catheterization |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with mixed venous oxygen saturation (SvO2) |
mixed venous oxygen saturation (SvO2) measured by right heart catheterization |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with right atrium area (RA-area) |
right atrium area (RA-area) determined by echocardiography |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with right ventricle area (RV-area) |
right ventricle area (RV-area) determined by echocardiography |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with myocardial performance index (Tei) |
myocardial performance index (Tei) determined by echocardiography |
at enrollment |
|
Secondary |
Correlation of BMPR2 expression levels with tricuspid annular plane systolic excursion (TAPSE) |
tricuspid annular plane systolic excursion (TAPSE) determined by echocardiography |
at enrollment |
|
Secondary |
Correlation of BMPR2 Expression with systolic pulmonary artery pressure |
systolic pulmonary artery pressure determined by echocardiography |
at enrollment |
|
Secondary |
Correlation of BMPR2 Expression with right ventricular function |
right ventricular function determined by echocardiography |
at enrollment |
|
Secondary |
Correlation of BMPR2 Expression with left ventricular function |
left ventricular function determined by echocardiography |
at enrollment |
|
Secondary |
Correlation of BMPR2 Expression with right ventricular pressure |
systolic, diastolic and mean right ventricular pressure measured by right heart catheterization |
at enrollment |
|
Secondary |
Correlation of BMPR2 Expression with pulmonary artery pressure |
systolic, diastolic and mean pulmonary artery pressure measured by right heart catheterization |
at enrollment |
|
Secondary |
Correlation of BMPR2 Expression with pulmonary vascular resistance |
pulmonary vascular resistance measured by right heart catheterization |
at enrollment |
|