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Pilot Study of the Safety and Efficacy of Anakinra in Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension Clinical Trial

Official title:
Pilot Study of the Safety and Efficacy of Anakinra in Pulmonary Arterial Hypertension

Clinical Trial Summary

Pulmonary arterial hypertension (PAH) can result in right ventricular failure and death. Anakinra has been used in patients with left sided heart failure, and the present study looks to determine if anakinra is safe and effective in patients with PAH. To accomplish this goal, we plan to evaluate for exercise improvement (as assessed by cardiopulmonary exercise testing) in 10 patients with PAH on anakinra.

Clinical Trial Description

Patients with pulmonary arterial hypertension will undergo cardiopulmonary exercise testing (CPET) at baseline and at 2 weeks. After the initial CPET, all patients will receive anakinra as a daily injection for 2 weeks. Patients will be instructed in the use of anakinra during their initial visit. Our primary outcome will be the difference in the exercise capacity of patients with PAH, as measured by maximal uptake of oxygen on CPET. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03057028
Study type Interventional
Source Virginia Commonwealth University
Contact
Status Completed
Phase Phase 1
Start date April 2016
Completion date June 7, 2018
View Details
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